The timing of neuronal loss across adolescence in the medial prefrontal cortex of male and female rats

Highlights • Female rats lose neurons in the medial prefrontal cortex between postnatal days 35 and 45. • Males do not lose a significant number of neurons from preadolescence to adulthood. • There were no changes in glial cell number in males or females from preadolescence to adulthood. • Males and...

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Bibliographic Details
Published in:Neuroscience 2015-08, Vol.301, p.268-275
Main Authors: Willing, J, Juraska, J.M
Format: Article
Language:English
Subjects:
adolescence
Aging
Analysis of Variance
Animals
Cell Count
Female
gamma-Aminobutyric Acid - metabolism
Male
Neuroglia - physiology
Neurology
Neurons - physiology
prefrontal cortex
Prefrontal Cortex - cytology
pruning
Rats
Rats, Long-Evans
Sex Characteristics
stereology
Stereotaxic Techniques
White Matter - pathology
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Summary:Highlights • Female rats lose neurons in the medial prefrontal cortex between postnatal days 35 and 45. • Males do not lose a significant number of neurons from preadolescence to adulthood. • There were no changes in glial cell number in males or females from preadolescence to adulthood. • Males and females gained white matter under the frontal cortex during this time.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.05.073