Polymerase chain reaction: a sensitive method for detecting Helicobacter pylori infection in bleeding peptic ulcers

To assess the sensitivity and specificity of polymerase chain reaction (PCR) in detecting Helicobacter pylori (H pylori) infection in patients with bleeding peptic ulcers, and to compare its diagnostic efficacy with other invasive and non-invasive tests. From April to September 2002, H pylori status...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2005-07, Vol.11 (25), p.3909-3914
Main Authors: Lo, Ching-Chu, Lai, Kwok-Hung, Peng, Nan-Jing, Lo, Gin-Ho, Tseng, Hui-Hwa, Lin, Chiun-Ku, Shie, Chang-Bih, Wu, Chao-Ming, Chen, Yu-Shan, Huang, Wen-Keui, Chen, Angela, Hsu, Ping-I
Format: Article
Language:English
Subjects:
Aged
Brief Reports
Female
Helicobacter Infections - complications
Helicobacter Infections - diagnosis
Helicobacter pylori
Humans
Male
Middle Aged
Peptic Ulcer Hemorrhage - complications
Peptic Ulcer Hemorrhage - microbiology
Polymerase Chain Reaction - standards
Sensitivity and Specificity
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Summary:To assess the sensitivity and specificity of polymerase chain reaction (PCR) in detecting Helicobacter pylori (H pylori) infection in patients with bleeding peptic ulcers, and to compare its diagnostic efficacy with other invasive and non-invasive tests. From April to September 2002, H pylori status in 60 patients who consecutively presented with gastroduodenal ulcer bleeding was examined by rapid urease tests (RUT), histology, culture, PCR, serology and urea breath tests (UBT). The sensitivity of PCR was significantly higher than that of RUT, histology and culture (91% vs 66%, 43% and 37%, respectively; P = 0.01,
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v11.i25.3909