In Vitro and In Vivo Efficacy of Amphotericin B Combined with Posaconazole against Experimental Disseminated Sporotrichosis

We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against spor...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2015-08, Vol.59 (8), p.5018-5021
Main Authors: Mario, Débora Nunes, Guarro, Josep, Santurio, Janio Morais, Alves, Sydney Hartz, Capilla, Javier
Format: Article
Language:English
Subjects:
Amphotericin B
Amphotericin B - therapeutic use
Animals
Antifungal Agents
Antifungal Agents - therapeutic use
Drug Resistance, Multiple, Fungal
Drug Therapy, Combination
Mice
Microbial Sensitivity Tests
Pharmacology
Sporothrix
Sporothrix - drug effects
Sporothrix - pathogenicity
Sporothrix schenckii
Sporotrichosis
Sporotrichosis - drug therapy
Triazoles
Triazoles - therapeutic use
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Summary:We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. This combination might be an option against disseminated sporotrichosis, especially when itraconazole or amphotericin B at optimal doses are contraindicated.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00052-15