Resistance Development: A Major Piece in the Jigsaw Puzzle of Tumor Size Modeling

Mathematical models of tumor size (TS) dynamics and tumor growth inhibition (TGI) need to place more emphasis on resistance development, given its relevant implications for clinical outcomes. A deeper understanding of the underlying processes, and effective data integration at different complexity l...

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Bibliographic Details
Published in:CPT: pharmacometrics and systems pharmacology 2015-06, Vol.4 (6), p.320-323
Main Authors: Terranova, N, Girard, P, Klinkhardt, U, Munafo, A
Format: Article
Language:English
Subjects:
Cancer therapies
Clinical trials
Cloning
Drug resistance
Evolution
Mutation
Patients
Tumors
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Summary:Mathematical models of tumor size (TS) dynamics and tumor growth inhibition (TGI) need to place more emphasis on resistance development, given its relevant implications for clinical outcomes. A deeper understanding of the underlying processes, and effective data integration at different complexity levels, can foster the incorporation of new mechanistic aspects into modeling approaches, improving anticancer drug effect prediction. As such, we propose a general framework for developing future semi‐mechanistic TS/TGI models of drug resistance.
ISSN:2163-8306
2163-8306
DOI:10.1002/psp4.45