Effects of vocal fold epithelium removal on vibration in an excised human larynx model

This study investigated the impact of selective epithelial injury on phonation in an excised human larynx apparatus. With intact epithelium, the vocal folds exhibited a symmetrical vibration pattern with complete glottal closure during vibration. The epithelium was then enzymatically removed from on...

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Bibliographic Details
Published in:The Journal of the Acoustical Society of America 2015-07, Vol.138 (1), p.EL60-EL64
Main Authors: Tse, Justin R, Zhang, Zhaoyan, Long, Jennifer L
Format: Article
Language:English
Subjects:
Aged
Cadaver
Female
Humans
Jasa Express Letters
Laryngeal Mucosa - physiology
Larynx - physiology
Male
Middle Aged
Phonation - physiology
Vibration
Vocal Cords - physiology
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Summary:This study investigated the impact of selective epithelial injury on phonation in an excised human larynx apparatus. With intact epithelium, the vocal folds exhibited a symmetrical vibration pattern with complete glottal closure during vibration. The epithelium was then enzymatically removed from one, then both vocal folds, which led to left-right asymmetric vibration and a decreased closed quotient. Although the mechanisms underlying these vibratory changes are unclear, these results demonstrate that some component of an intact surface layer may play an important role in achieving normal symmetric vibration and glottal closure.
ISSN:0001-4966
1520-8524
DOI:10.1121/1.4922765