Bamboo leaf extract improves spatial learning ability in a rat model with senile dementia

• Published in: Journal of Zhejiang University. B. Science 2015-07, Vol.16 (7), p.593-601
• Main Authors: Liu, Jian-xiang, Zhu, Min-ying, Feng, Ci-yuan, Ding, Hai-bin, Zhan, Ying, Zhao, Zhan, Ding, Yue-min
• Format: Article
• Language: English
• Subjects: acetylcholine; acetylcholinesterase; Alzheimer Disease - complications; Alzheimer Disease - drug therapy; Alzheimer Disease - physiopathology; amine oxidase (flavin-containing); animal models; Animals; antineoplastic activity; antioxidants; bamboos; Biomedical and Life Sciences; Biomedicine; China; dementia; dopamine; enzyme activity; epinephrine; gamma-aminobutyric acid; glutamic acid; hippocampus; leaf extracts; Male; memory; Memory Disorders - drug therapy; Memory Disorders - etiology; Memory Disorders - physiopathology; neurotransmitters; norepinephrine; Plant Extracts - administration & dosage; Plant Leaves - chemistry; Rats; Rats, Sprague-Dawley; Sasa - chemistry; Spatial Learning - drug effects; therapeutics; Treatment Outcome
• ISSN: 1673-1581; 1862-1783
• DOI: 10.1631/jzus.B1400249

Senile dementia (SD) is a syndrome characterized by progressive neurological deterioration. Treatment for the disease is still under investigation. Bamboo leaf extract (B-extract) has been known for its biological efficacy in anti-oxidant and anti-cancer activities. However, study on B-extract for its protection against dementia is very limited. The effect of B-extract on a rat model with SD was examined. B-extract improved spatial learning ability of the dementia rats. The hippocampus of dementia model rats showed reduced levels of acetylcholine (ACh), epinephrine (E), norepinephrine (NE), and dopamine (DA), and increased activities of acetylcholine esterase (AChE) and monoamine oxidase (MAO). Treatment with B-extract 20 mg/(kg·d) for 7 weeks significantly inhibited the enzyme activity compared with untreated dementia rats, and raised the levels of ACh, E, and DA in the hippocampus. In addition, treatment with B-extract elevated the level of γ-aminobutyric acid (GABA), but reduced the level of glutamate (Glu) in the brain. These data suggest that B-extract might be a potential drug in treating impairment of spatial memory in dementia rats by regulating the central neurotransmitter function.