Complex inhibitory microcircuitry regulates retinal signaling near visual threshold

Neuronal microcircuits, small, localized signaling motifs involving two or more neurons, underlie signal processing and computation in the brain. Compartmentalized signaling within a neuron may enable it to participate in multiple, independent microcircuits. Each A17 amacrine cell in the mammalian r...

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Bibliographic Details
Published in:Journal of neurophysiology 2015-07, Vol.114 (1), p.341-353
Main Authors: Grimes, William N, Zhang, Jun, Tian, Hua, Graydon, Cole W, Hoon, Mrinalini, Rieke, Fred, Diamond, Jeffrey S
Format: Article
Language:English
Subjects:
Animals
Calcium Channels, L-Type - metabolism
Darkness
Feedback, Physiological - physiology
Immunohistochemistry
Immunoprecipitation
Large-Conductance Calcium-Activated Potassium Channels - metabolism
Mice, Inbred C57BL
Neural Inhibition - physiology
Patch-Clamp Techniques
Photic Stimulation
Rats, Sprague-Dawley
Receptors, GABA - metabolism
Retina - cytology
Retina - physiology
Sensory Processing
Sensory Thresholds - physiology
Synapses - physiology
Tissue Culture Techniques
Vision, Ocular - physiology
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Summary:Neuronal microcircuits, small, localized signaling motifs involving two or more neurons, underlie signal processing and computation in the brain. Compartmentalized signaling within a neuron may enable it to participate in multiple, independent microcircuits. Each A17 amacrine cell in the mammalian retina contains within its dendrites hundreds of synaptic feedback microcircuits that operate independently to modulate feedforward signaling in the inner retina. Each of these microcircuits comprises a small (
ISSN:0022-3077
1522-1598
DOI:10.1152/jn.00017.2015