Early postnatal respiratory viral infection induces structural and neurochemical changes in the neonatal piglet brain

Highlights • Early-life respiratory viral infection impacts brain development in piglets. • Infected piglets had region specific reductions in grey and white matter volume. • Infected piglets had a trend for reduced FA in the corpus callosum. • Infected piglets had a disrupted neurochemical balance...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2015-08, Vol.48, p.326-335
Main Authors: Conrad, Matthew S, Sutton, Bradley P, Larsen, Ryan, Van Alstine, William G, Johnson, Rodney W
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Animals, Newborn
Brain
Brain - metabolism
Brain - pathology
Brain - virology
Development
Infection
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Neonatal
Organ Size
Pig
Porcine Reproductive and Respiratory Syndrome - metabolism
Porcine Reproductive and Respiratory Syndrome - pathology
Porcine Reproductive and Respiratory Syndrome - virology
Porcine respiratory and reproductive syndrome virus
Psychiatry
Swine
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Summary:Highlights • Early-life respiratory viral infection impacts brain development in piglets. • Infected piglets had region specific reductions in grey and white matter volume. • Infected piglets had a trend for reduced FA in the corpus callosum. • Infected piglets had a disrupted neurochemical balance in the hippocampus.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2015.05.001