Diverse Roles of Heparan Sulfate and Heparin in Wound Repair

Heparan sulfate (HS) and heparin (Hp) are linear polysaccharide chains composed of repeating (1 → 4) linked pyrosulfuric acid and 2-amino-2-deoxy glucopyranose (glucosamine) residue. Mentioned glycosaminoglycans chains are covalently O-linked to serine residues within the core proteins creating hepa...

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Bibliographic Details
Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-7
Main Authors: Olczyk, Pawel, Komosinska-Vassev, Katarzyna, Mencner, Łukasz
Format: Article
Language:English
Subjects:
Acids
Angiogenesis
Animals
Biosynthesis
Care and treatment
Cell growth
Chemokines
Colleges & universities
Cytokines
Dosage and administration
Extracellular matrix
Free radicals
Growth factors
Heparan sulfate
Heparin
Heparin - biosynthesis
Heparin - chemistry
Heparin - pharmacology
Heparitin Sulfate - biosynthesis
Heparitin Sulfate - chemistry
Heparitin Sulfate - pharmacology
Humans
Influence
Laboratories
Pharmacy
Proteins
Review
Skin
Wound healing
Wound Healing - drug effects
Wounds and injuries
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Summary:Heparan sulfate (HS) and heparin (Hp) are linear polysaccharide chains composed of repeating (1 → 4) linked pyrosulfuric acid and 2-amino-2-deoxy glucopyranose (glucosamine) residue. Mentioned glycosaminoglycans chains are covalently O-linked to serine residues within the core proteins creating heparan sulfate/heparin proteoglycans (HSPG). The latter ones participate in many physiological and pathological phenomena impacting both the plethora of ligands such as cytokines, growth factors, and adhesion molecules and the variety of the ECM constituents. Moreover, HS/Hp determine the effective wound healing process. Initial growth of HS and Hp amount is pivotal during the early phase of tissue repair; however heparan sulfate and heparin also participate in further stages of tissue regeneration.
ISSN:2314-6133
2314-6141
2314-6141
DOI:10.1155/2015/549417