The importance of ubiquitin E3 ligases, SCF and APC/C, in human cancers

     A normal evolution of the cell-cycle phases consists of multiple consecutive events, which makes it a highly complex process. Its preservation is regulated by Cyclin-Cdks (cyclin-dependent kinases) interactions and protein degradation, which is often controlled by the ubiquitin-mediated proteol...

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Bibliographic Details
Published in:Clujul medical 2015, Vol.88 (1), p.9-14
Main Authors: Bochis, Ovidiu Vasile, Fetica, Bogdan, Vlad, Catalin, Achimas-Cadariu, Patriciu, Irimie, Alexandru
Format: Article
Language:English
Subjects:
Review
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Summary:     A normal evolution of the cell-cycle phases consists of multiple consecutive events, which makes it a highly complex process. Its preservation is regulated by Cyclin-Cdks (cyclin-dependent kinases) interactions and protein degradation, which is often controlled by the ubiquitin-mediated proteolysis.The goal of this review is to emphasize the most important features of the regulation of the cell-cycle involved in cancerogenesis, by presenting the involvement of E3 ubiquitin ligases SCF (Skp1-Cul1-F-box protein) and APC/C (Anaphase-promoting complex/cyclosome) in human malignancies. Also, we discuss the importance of the ubiquitin proteasome pathway blockade in cancer treatment. We know that a better understanding of the regulatory biology of the cell cycle can lead to the development of new target therapies for cancer.
ISSN:2602-0807
1222-2119
2668-0572
2066-8872
DOI:10.15386/cjmed-377