Aberrant methylation of CDH11 predicts a poor outcome for patients with bladder cancer

DNA methylation is one of the major mechanisms via which tumor suppressor gene inactivation occurs. For example, hypermethylation of the promoter region of cadherin 11 (CDH11), a novel tumor suppressor gene, frequently occurs in human cancer. In the current study, the methylation status of CDH11 was...

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Bibliographic Details
Published in:Oncology letters 2015-08, Vol.10 (2), p.647-652
Main Authors: LIN, YING-LI, GUI, SHI-LIANG, MA, JIAN-GUO
Format: Article
Language:English
Subjects:
Biomarkers
Bladder cancer
cadherin 11
Cadherins
Cancer research
Deoxyribonucleic acid
DNA
DNA methylation
Epigenetics
Genes
Genetic testing
Health risk assessment
Medical prognosis
Methylation
Oncology
Physiological aspects
Prognosis
Studies
Surveillance
Tumors
Urology
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Summary:DNA methylation is one of the major mechanisms via which tumor suppressor gene inactivation occurs. For example, hypermethylation of the promoter region of cadherin 11 (CDH11), a novel tumor suppressor gene, frequently occurs in human cancer. In the current study, the methylation status of CDH11 was investigated in bladder cancer tissue samples, and the correlation with clinicopathological features and patient outcome was assessed. The methylation status of CDH11 was detected in 146 bladder cancer tissues and 37 normal bladder epithelial tissues using methylation-specific polymerase chain reaction (PCR). In addition, CDH11 mRNA expression levels were examined by quantitative PCR. Subsequently, associations between CDH11 methylation and specific clinicopathological characteristics, as well as patient outcome, were analyzed. Aberrant CDH11 promoter hypermethylation was detected in 63.0% (92/146) of bladder cancer tissues, however, no CDH11 methylation was identified in the control samples; this difference was significant (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2015.3337