Effects of chronic binge-like ethanol consumption on cocaine self-administration in rhesus monkeys

Highlights • Chronic EtOH consumption increased self-administration of low cocaine doses. • Self-administration returned to baseline after EtOH drinking was discontinued. • EtOH drinking enhanced quinpirole-induced yawning in two of three monkeys. • Cocaine self-administration was not increased afte...

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Bibliographic Details
Published in:Drug and alcohol dependence 2015-08, Vol.153, p.278-285
Main Author: Czoty, Paul W
Format: Article
Language:English
Subjects:
Alcohol
Animals
Co-abuse
Cocaine
Cocaine - administration & dosage
Dopamine Agonists - pharmacology
Dopamine Antagonists - pharmacology
Dose-Response Relationship, Drug
Drug Interactions
Ethanol - administration & dosage
Ethanol - pharmacology
Macaca mulatta
Male
Nonhuman primates
Psychiatry
Quinpirole - pharmacology
Receptors, Dopamine - metabolism
Reinforcement (Psychology)
Reinforcement Schedule
Self Administration
Yawning - drug effects
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Summary:Highlights • Chronic EtOH consumption increased self-administration of low cocaine doses. • Self-administration returned to baseline after EtOH drinking was discontinued. • EtOH drinking enhanced quinpirole-induced yawning in two of three monkeys. • Cocaine self-administration was not increased after acute EtOH exposure.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2015.05.016