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Effects of chronic binge-like ethanol consumption on cocaine self-administration in rhesus monkeys

Highlights • Chronic EtOH consumption increased self-administration of low cocaine doses. • Self-administration returned to baseline after EtOH drinking was discontinued. • EtOH drinking enhanced quinpirole-induced yawning in two of three monkeys. • Cocaine self-administration was not increased afte...

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Published in:	Drug and alcohol dependence 2015-08, Vol.153, p.278-285
Main Author:	Czoty, Paul W
Format:	Article
Language:	English
Subjects:	Alcohol Animals Co-abuse Cocaine Cocaine - administration & dosage Dopamine Agonists - pharmacology Dopamine Antagonists - pharmacology Dose-Response Relationship, Drug Drug Interactions Ethanol - administration & dosage Ethanol - pharmacology Macaca mulatta Male Nonhuman primates Psychiatry Quinpirole - pharmacology Receptors, Dopamine - metabolism Reinforcement (Psychology) Reinforcement Schedule Self Administration Yawning - drug effects
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container_title	Drug and alcohol dependence
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description	Highlights • Chronic EtOH consumption increased self-administration of low cocaine doses. • Self-administration returned to baseline after EtOH drinking was discontinued. • EtOH drinking enhanced quinpirole-induced yawning in two of three monkeys. • Cocaine self-administration was not increased after acute EtOH exposure.
doi_str_mv	10.1016/j.drugalcdep.2015.05.016
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source	ScienceDirect Journals; Science Direct
subjects	Alcohol Animals Co-abuse Cocaine Cocaine - administration & dosage Dopamine Agonists - pharmacology Dopamine Antagonists - pharmacology Dose-Response Relationship, Drug Drug Interactions Ethanol - administration & dosage Ethanol - pharmacology Macaca mulatta Male Nonhuman primates Psychiatry Quinpirole - pharmacology Receptors, Dopamine - metabolism Reinforcement (Psychology) Reinforcement Schedule Self Administration Yawning - drug effects
title	Effects of chronic binge-like ethanol consumption on cocaine self-administration in rhesus monkeys
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