Natural progression of atherosclerosis from pathologic intimal thickening to late fibroatheroma in human coronary arteries: A pathology study

Abstract Objective Smooth muscle cells, macrophage infiltration and accumulation of lipids, proteoglycans, collagen matrix and calcification play a central role in atherosclerosis. The early histologic changes of plaque progression from pathologic intimal thickenings (PIT) to late fibroatheroma lesi...

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Published in:Atherosclerosis 2015-08, Vol.241 (2), p.772-782
Main Authors: Otsuka, Fumiyuki, Kramer, Miranda C.A, Woudstra, Pier, Yahagi, Kazuyuki, Ladich, Elena, Finn, Aloke V, de Winter, Robbert J, Kolodgie, Frank D, Wight, Thomas N, Davis, Harry R, Joner, Michael, Virmani, Renu
Format: Article
Language:English
Subjects:
Adult
Apoptosis
Atherosclerosis
Atherosclerosis - pathology
Calcification
Calcinosis
Cardiovascular
Coronary Artery Disease - pathology
Coronary Vessels - pathology
Disease Progression
Extracellular matrix
Extracellular Matrix - metabolism
Female
Humans
Immunohistochemistry
Inflammation
Lipids - blood
Macrophage
Macrophages - metabolism
Male
Middle Aged
Pathology
Plaque, Atherosclerotic - pathology
Prevalence
Proteoglycans
Proteoglycans - metabolism
Retrospective Studies
Tunica Intima - pathology
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Summary:Abstract Objective Smooth muscle cells, macrophage infiltration and accumulation of lipids, proteoglycans, collagen matrix and calcification play a central role in atherosclerosis. The early histologic changes of plaque progression from pathologic intimal thickenings (PIT) to late fibroatheroma lesions have not been fully characterized. Methods A total of 151 atherosclerotic coronary lesions were collected from 67 sudden death victims. Atherosclerotic plaques were classified as PIT without macrophage infiltration, PIT with macrophages, and early and late fibroatheromas. Presence of macrophages and proteoglycans (versican, decorin and biglycan) were recognized by specific antibodies while hyaluronan was detected by affinity histochemistry. Lipid deposition was identified by oil-red-O, and calcification was assessed following von Kossa and alizarin red staining. Results Lesion progression from PIT to late fibroatheroma was associated with increase in macrophage accumulation (p 
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2015.05.011