ThermoTRPs and Pain

The ability of the body to perceive noxious stimuli lies in a heterogeneous group of primary somatosensory neurons termed nociceptors. The molecular receptors of noxious mechanical, temperature, or chemical stimuli are expressed in these neurons and have drawn considerable attention as possible targ...

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Bibliographic Details
Published in:The Neuroscientist 2016-04, Vol.22 (2), p.171-187
Main Authors: Laing, Robyn J, Dhaka, Ajay
Format: Article
Language:English
Subjects:
Animals
Humans
Hyperalgesia - genetics
Hyperalgesia - physiopathology
Models, Molecular
Nociceptors - physiology
Pain - genetics
Physical Stimulation
Transient Receptor Potential Channels - physiology
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Summary:The ability of the body to perceive noxious stimuli lies in a heterogeneous group of primary somatosensory neurons termed nociceptors. The molecular receptors of noxious mechanical, temperature, or chemical stimuli are expressed in these neurons and have drawn considerable attention as possible targets for analgesic development to improve treatment for the millions who suffer from chronic pain conditions. A number of thermoTRPs, a subset of the transient receptor potential family of ion channels, are activated by a wide range on noxious stimuli. In this review, we review the function of these channels and examine the evidence that thermoTRPs play a vital role in acute, inflammatory and neuropathic nociception.
ISSN:1073-8584
1089-4098
DOI:10.1177/1073858414567884