Update on Biomarkers for the Detection of Endometriosis

Endometriosis is histologically characterized by the displacement of endometrial tissue to extrauterine locations including the pelvic peritoneum, ovaries, and bowel. An important cause of infertility and pelvic pain, the individual and global socioeconomic burden of endometriosis is significant. La...

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Bibliographic Details
Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-14
Main Authors: D’Hooghe, Thomas, O, Dorien F., Burney, Richard O., Fassbender, Amelie, Giudice, Linda
Format: Article
Language:English
Subjects:
Biological markers
Biomarkers
Biomarkers - blood
Biomarkers - metabolism
Biomarkers - urine
Development and progression
Diagnosis
Early Diagnosis
Endometriosis
Endometriosis - diagnosis
Endometriosis - metabolism
Endometrium - metabolism
Female
Fluids
Gynecology
Humans
Infertility
Laparoscopy
Menstruation
Nonsteroidal anti-inflammatory drugs
Obstetrics
Pain
Physiological aspects
Quality standards
Reproducibility of Results
Review
Sample size
Sensitivity and Specificity
Studies
Surgery
Ultrasonic imaging
Urine
Womens health
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Summary:Endometriosis is histologically characterized by the displacement of endometrial tissue to extrauterine locations including the pelvic peritoneum, ovaries, and bowel. An important cause of infertility and pelvic pain, the individual and global socioeconomic burden of endometriosis is significant. Laparoscopy remains the gold standard for the diagnosis of the condition. However, the invasive nature of surgery, coupled with the lack of a laboratory biomarker for the disease, results in a mean latency of 7–11 years from onset of symptoms to definitive diagnosis. Unfortunately, the delay in diagnosis may have significant consequences in terms of disease progression. The discovery of a sufficiently sensitive and specific biomarker for the nonsurgical detection of endometriosis promises earlier diagnosis and prevention of deleterious sequelae and represents a clear research priority. In this review, we describe and discuss the current status of biomarkers of endometriosis in plasma, urine, and endometrium.
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/130854