Prognostic significance of neutrophil-to-lymphocyte ratio in non-small cell lung cancer: a meta-analysis

Published data on the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) in non-small cell lung cancer (NSCLC) are controversial. We performed a meta-analysis to more accurately assess its prognostic value. The analysis was performed based on the data from 14 studies with 3,656 patients...

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Bibliographic Details
Published in:Scientific reports 2015-07, Vol.5 (1), p.12493-12493, Article 12493
Main Authors: Gu, Xiao-Bin, Tian, Tian, Tian, Xiao-Jing, Zhang, Xiao-Jun
Format: Article
Language:English
Subjects:
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Carcinoma, Non-Small-Cell Lung - blood
Carcinoma, Non-Small-Cell Lung - mortality
Data processing
Disease-Free Survival
Female
Heterogeneity
Humanities and Social Sciences
Humans
Lung cancer
Lung Neoplasms - blood
Lung Neoplasms - mortality
Lymphocyte Count
Lymphocytes
Male
Medical prognosis
Meta-analysis
multidisciplinary
Neutrophils
Non-small cell lung carcinoma
Regression analysis
Science
Survival
Survival Rate
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Summary:Published data on the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) in non-small cell lung cancer (NSCLC) are controversial. We performed a meta-analysis to more accurately assess its prognostic value. The analysis was performed based on the data from 14 studies with 3,656 patients to estimate the correlation between NLR and overall survival (OS) and progression-free survival (PFS) in NSCLC. Hazard ratio (HR) with 95% confidence interval (CI) were calculated to estimate the effect. We also conducted subgroup analysis and meta-regression analysis. The results demonstrated that elevated pretreatment NLR predicted poorer OS (HR: 1.70, 95% CI: 1.39–2.09) and PFS (HR: 1.63, 95% CI: 1.27–2.09) in patients with NSCLC. Subgroup analysis indicated that cut-off value of 5 showed consistently prognostic value. There was no significant heterogeneity or publication bias for OS and PFS for included studies. This meta-analysis revealed that elevated pretreatment NLR might be a predicative factor of poor prognosis for NSCLC patients.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep12493