Assessment of dipyridamole stress echocardiography for risk stratification of diabetic patients

Despite advances in medical therapy, cardiovascular disease, mainly coronary artery disease (CAD), remains the leading cause of mortality among patients with diabetes mellitus (DM). The objective of the present study was to assess the effectiveness of dipyridamole stress echocardiography in identify...

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Bibliographic Details
Published in:Cardiovascular ultrasound 2015-07, Vol.13 (1), p.35-35, Article 35
Main Authors: Baroncini, Liz Andréa Villela, Borsoi, Rafael, Vidal, Maria Eugênia Bégué, Valente, Nathália Julim, Veloso, Juliana, Pecoits Filho, Roberto
Format: Article
Language:English
Subjects:
Brazil - epidemiology
Comorbidity
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - mortality
Diabetes Complications - diagnostic imaging
Diabetes Complications - mortality
Dipyridamole
Echocardiography, Stress - statistics & numerical data
Exercise Test
Female
Humans
Incidence
Male
Middle Aged
Prognosis
Reproducibility of Results
Risk Assessment - methods
Sensitivity and Specificity
Survival Analysis
Vasodilator Agents
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Summary:Despite advances in medical therapy, cardiovascular disease, mainly coronary artery disease (CAD), remains the leading cause of mortality among patients with diabetes mellitus (DM). The objective of the present study was to assess the effectiveness of dipyridamole stress echocardiography in identify diabetic patients at high risk for cardiovascular events. Dipyridamole stress echocardiography was administered to 483 diabetic patients (294 women; mean age 63.41 ± 11.28 years) between July 2006 and December 2012. Follow-up data were available for 264 patients (163 women; mean age 64.3 ± 10.5 years): 250 with a negative stress echocardiography and 14 with a positive stress echo. During a mean follow-up time of 18 ± 14 months, a cardiovascular event occurred in 18 (6.8%) patients, 12 (4.8%) in patients with a negative stress echo (n = 250) during a mean follow-up period of 20 ± 16 months and 6 (42%) in patients with positive stress echo (n = 14) during a mean follow-up of 13 ± 13 months. The positive and negative predictive values of stress echocardiography were 42% and 96% respectively. The accuracy value was 92%. A Cox regression model showed that CAD (hazard ratio [HR] 5.4, 95% confidence interval [CI] 1.9-15.4; p = 0.002) and positive stress echocardiography (HR 7.1, 95% CI 2.5-20.5; p 
ISSN:1476-7120
1476-7120
DOI:10.1186/s12947-015-0030-7