Anti-mullerian hormone (AMH) is associated with natural menopause in a population-based sample: The CARDIA Women's Study

Abstract Objective AMH is associated with menopausal timing in several studies. In contrast to prior studies that were restricted to women with regular cycles, our objective was to examine this association in women with either regular or irregular menstrual cycles. Methods CARDIA is a longitudinal,...

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Published in:Maturitas 2015-08, Vol.81 (4), p.493-498
Main Authors: Nair, Sangeeta, Slaughter, James C, Terry, James G, Appiah, Duke, Ebong, Imo, Wang, Erica, Siscovick, David S, Sternfeld, Barbara, Schreiner, Pamela J, Lewis, Cora E, Kabagambe, Edmond K, Wellons, Melissa F
Format: Article
Language:English
Subjects:
Adult
Anti-mullerian hormone
Anti-Mullerian Hormone - blood
Biomarkers - blood
CARDIA
Female
FSH
Humans
Internal Medicine
Menopause
Menopause - blood
Menstruation - blood
Middle Aged
Obstetrics and Gynecology
Ovarian aging
Ovarian reserve
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Summary:Abstract Objective AMH is associated with menopausal timing in several studies. In contrast to prior studies that were restricted to women with regular cycles, our objective was to examine this association in women with either regular or irregular menstrual cycles. Methods CARDIA is a longitudinal, population-based study that recruited adults ages 18–30 when it began in 1985–1986. AMH was measured in serum stored in 2002–2003. Natural menopause was assessed by survey in 2005–2006 and 2010–2011. Results Among 716 premenopausal women, median [25th, 75th] AMH was 0.77 [0.22–2.02] ng/dL at a median age of 42 [39–45] years. Twenty-nine percent of the women ( n = 207) reported natural menopause during 9 years of follow up. In fully adjusted discrete-time hazard models, a 0.5 ng/dL AMH decrement was associated with higher risk of menopause ( p < 0.001). Hazard ratios varied with time since AMH measurement. The HR (95% CI) for menopause was 8.1 (2.5–26.1) within 0–3 years and 2.3 (1.7–3.3) and 1.6 (1.3–2.1) for 3–6 and 6–9 years, respectively. When restricted to women with regular menses, results were similar (e.g., HR = 6.1; 95% CI: 1.9–20.0 for 0–3 years). Conclusion AMH is independently associated with natural menopause. AMH appears most useful in identifying women at risk of menopause in the near future (within 3 years of AMH measurement).
ISSN:0378-5122
1873-4111
DOI:10.1016/j.maturitas.2015.06.026