Radiotherapy influences local control in patients with desmoplastic melanoma

BACKGROUND Desmoplastic melanoma may have a high risk of local recurrence after wide excision. The authors hypothesized that adjuvant radiotherapy (RT) would improve local control in patients with desmoplastic melanoma, resulting in at least a 10% absolute decrease in local recurrence rate. METHODS...

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Bibliographic Details
Published in:Cancer 2014-05, Vol.120 (9), p.1369-1378
Main Authors: Strom, Tobin, Caudell, Jimmy J., Han, Dale, Zager, Jonathan S., Yu, Daohai, Cruse, C. Wayne, Marzban, Suroosh S., Messina, Jane L., Trotti, Andy M., Sondak, Vernon K., Rao, Nikhil G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
control
Dermatology
desmoplastic
Female
Follow-Up Studies
Humans
local neoplasm recurrence
Male
Medical sciences
melanoma
Melanoma - pathology
Melanoma - radiotherapy
Melanoma - surgery
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - prevention & control
radiation
radiotherapy
Radiotherapy, Adjuvant
Retrospective Studies
Skin Neoplasms - pathology
Skin Neoplasms - radiotherapy
Skin Neoplasms - secondary
Tumors
Tumors of the skin and soft tissue. Premalignant lesions
Young Adult
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Summary:BACKGROUND Desmoplastic melanoma may have a high risk of local recurrence after wide excision. The authors hypothesized that adjuvant radiotherapy (RT) would improve local control in patients with desmoplastic melanoma, resulting in at least a 10% absolute decrease in local recurrence rate. METHODS A total of 277 patients from 1989 through 2010 who were treated for nonmetastatic desmoplastic melanoma by surgery with or without adjuvant RT were reviewed. Clinicopathologic and treatment variables were assessed with regard to their role in local control. RESULTS A total of 113 patients (40.8%) received adjuvant RT. After a median follow‐up of 43.1 months, adjuvant RT was found to be independently associated with improved local control on multivariable analysis (hazards ratio, 0.15; 95% confidence interval, 0.06‐0.39 [P  4 mm, or a Clark level V tumor, RT was found to significantly improve local control (P 
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.28412