Age at Menarche and Cardiometabolic Risk in Adulthood: The Coronary Artery Risk Development in Young Adults Study

Objective To examine the association of menarche timing with cardiometabolic risk factors into early to mid-adulthood, comparing African American and White women. Study design Analyses included 2583 women (African American = 1333; White = 1250) from the Coronary Artery Risk Development in Young Adul...

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Bibliographic Details
Published in:The Journal of pediatrics 2015-08, Vol.167 (2), p.344-352.e1
Main Authors: Dreyfus, Jill, PhD, MPH, Jacobs, David R., PhD, Mueller, Noel, PhD, MPH, Schreiner, Pamela J., PhD, Moran, Antoinette, MD, Carnethon, Mercedes R., PhD, Demerath, Ellen W., PhD
Format: Article
Language:English
Subjects:
Adiposity
Adult
Age Factors
Black or African American - statistics & numerical data
Blood Glucose
Blood Pressure
Body Mass Index
Cardiovascular Diseases - epidemiology
Cohort Studies
Diabetes Mellitus, Type 2 - epidemiology
Female
Humans
Incidence
Lipids - blood
Menarche
Metabolic Syndrome - epidemiology
Middle Aged
Pediatrics
Risk Factors
White People - statistics & numerical data
Young Adult
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Summary:Objective To examine the association of menarche timing with cardiometabolic risk factors into early to mid-adulthood, comparing African American and White women. Study design Analyses included 2583 women (African American = 1333; White = 1250) from the Coronary Artery Risk Development in Young Adults cohort study over 25 years of follow-up (1985-2011). Outcomes included type 2 diabetes, metabolic syndrome, adiposity, glucose, insulin, blood pressure, and blood lipids. Cox models or repeated measures linear regression models estimated the association between age at menarche and the outcomes. Results Each 1-year earlier age at menarche was associated with higher mean body mass index among African American (0.88 ± 0.12 kg/m2 , P  
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2015.04.032