Lipoprotein heterogeneity in persons with Spinal Cord Injury: a model of prolonged sitting and restricted physical activity

Persons with spinal cord injury (SCI) often have low levels of physical activity, which predispose to increased adiposity and decreased high density lipoprotein cholesterol (HDL-C) concentrations, and, generally, normal low density lipoprotein cholesterol (LDL-C) concentrations. In spite of the mixe...

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Bibliographic Details
Published in:Lipids in health and disease 2015-07, Vol.14 (1), p.81, Article 81
Main Authors: La Fountaine, Michael F, Cirnigliaro, Christopher M, Emmons, Racine R, Kirshblum, Steven C, Galea, Marinella, Spungen, Ann M, Bauman, William A
Format: Article
Language:English
Subjects:
Adult
Analysis
Atoms & subatomic particles
Blood lipids
Body composition
Cardiovascular disease
Cardiovascular diseases
Cholesterol
Cholesterol, HDL - blood
Chronic illnesses
Cohort Studies
Data collection
Development and progression
Diabetes
Fasting - blood
Female
Health aspects
Humans
Insulin
Insulin - blood
Insulin Resistance
Lifestyles
Lipids
Lipoproteins - blood
Low density lipoprotein
Magnetic Resonance Spectroscopy
Male
Metabolism
Models, Biological
Morbidity
Motor Activity
NMR
Nuclear magnetic resonance
Particle Size
Physiological aspects
Population
Posture
R&D
Recruitment
Rehabilitation
Research & development
Spectrum analysis
Spinal cord injuries
Spinal Cord Injuries - blood
Spinal Cord Injuries - physiopathology
Studies
Triglycerides - blood
Veterans
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Summary:Persons with spinal cord injury (SCI) often have low levels of physical activity, which predispose to increased adiposity and decreased high density lipoprotein cholesterol (HDL-C) concentrations, and, generally, normal low density lipoprotein cholesterol (LDL-C) concentrations. In spite of the mixed lipoprotein profile, the SCI population has been reported to have an elevated risk of cardiovascular-related morbidity and mortality. Nuclear magnetic resonance spectroscopy may permit a more precise quantification of lipoprotein particle (P) species, enabling a more accurate inference of risk for cardiovascular disease (CVD) in the SCI population. Fasting blood samples were obtained on 83 persons with chronic SCI and 62 able-bodied (AB) subjects. Fasting plasma insulin (FPI), triglycerides (TG), and P number and size of VLDL (very low density lipoprotein), LDL, and HDL subclasses were determined. AB and SCI subjects were stratified based on HDL-C (i.e., Low
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-015-0084-4