Study on the Linezolid Prescription According to the Approval of Indication in a University Hospital

Indications for linezolid use are nosocomial or community-acquired pneumonia and skin infections or soft tissue infection caused by gram-positive microorganisms, but new recommendations may emerge. It is important to balance benefits with risks because severe adverse events have been described in pa...

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Published in:Iranian journal of pharmaceutical research : IJPR 2015-01, Vol.14 (3), p.857-864
Main Authors: Pérez-Cebrián, Manuela, Suárez-Varela, María M Morales, Font-Noguera, Isabel, Monte-Boquet, Emilio, Poveda-Andrés, Jose Luís, Martín-Moreno, Jose María, Rubio-López, Nuria, Ruiz-Rojo, Elias, Llopis-González, Agustín
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Language:English
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Summary:Indications for linezolid use are nosocomial or community-acquired pneumonia and skin infections or soft tissue infection caused by gram-positive microorganisms, but new recommendations may emerge. It is important to balance benefits with risks because severe adverse events have been described in patients taking linezolid treatment. Accordingly, we evaluated the suitability of linezolid prescription according to approval of indication by evaluating the presence of drug-related problems (DRP) in a University hospital. DRP were identified in 36 patients (50.0%). In most cases, they were related to known or established indications (15 patients, 20.8%), to safety (5 patients, 6.9%), and to both in others (16 patients, 22.2%). No DRP were recorded, which modified linezolid efficacy. DRP were significantly higher in the patients treated by an approved indication in Spain (63.3%) than in those treated by an unapproved indication in Spain (28.6%). We concluded that new studies about extending linezolid indications may be necessary.
ISSN:1735-0328
1726-6890