Risk of Adverse Pregnancy Outcomes in Women with CKD

CKD is increasingly prevalent in pregnancy. In the Torino-Cagliari Observational Study (TOCOS), we assessed whether the risk for adverse pregnancy outcomes is associated with CKD by comparing pregnancy outcomes of 504 pregnancies in women with CKD to outcomes of 836 low-risk pregnancies in women wit...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Society of Nephrology 2015-08, Vol.26 (8), p.2011-2022
Main Authors: Piccoli, Giorgina Barbara, Cabiddu, Gianfranca, Attini, Rossella, Vigotti, Federica Neve, Maxia, Stefania, Lepori, Nicola, Tuveri, Milena, Massidda, Marco, Marchi, Cecilia, Mura, Silvia, Coscia, Alessandra, Biolcati, Marilisa, Gaglioti, Pietro, Nichelatti, Michele, Pibiri, Luciana, Chessa, Giuseppe, Pani, Antonello, Todros, Tullia
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Clinical Research
Female
Humans
Logistic Models
Pregnancy
Pregnancy Complications - etiology
Pregnancy Outcome
Renal Insufficiency, Chronic - complications
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:CKD is increasingly prevalent in pregnancy. In the Torino-Cagliari Observational Study (TOCOS), we assessed whether the risk for adverse pregnancy outcomes is associated with CKD by comparing pregnancy outcomes of 504 pregnancies in women with CKD to outcomes of 836 low-risk pregnancies in women without CKD. The presence of hypertension, proteinuria (>1 g/d), systemic disease, and CKD stage (at referral) were assessed at baseline. The following outcomes were studied: cesarean section, preterm delivery, and early preterm delivery; small for gestational age (SGA); need for neonatal intensive care unit (NICU); new onset of hypertension; new onset/doubling of proteinuria; CKD stage shift; "general" combined outcome (preterm delivery, NICU, SGA); and "severe" combined outcome (early preterm delivery, NICU, SGA). The risk for adverse outcomes increased across stages (for stage 1 versus stages 4-5: "general" combined outcome, 34.1% versus 90.0%; "severe" combined outcome, 21.4% versus 80.0%; P
ISSN:1046-6673
1533-3450
DOI:10.1681/ASN.2014050459