Genome-wide whole blood microRNAome and transcriptome analyses reveal miRNA-mRNA regulated host response to foodborne pathogen Salmonella infection in swine

To understand the role of miRNAs in regulating genes involved in host response to bacterial infection and shedding of foodborne pathogens, a systematic profiling of miRNAs and mRNAs from the whole blood of pigs upon Salmonella challenge was performed. A total of 62 miRNAs were differentially express...

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Bibliographic Details
Published in:Scientific reports 2015-07, Vol.5 (1), p.12620-12620, Article 12620
Main Authors: Bao, Hua, Kommadath, Arun, Liang, Guanxiang, Sun, Xu, Arantes, Adriano S., Tuggle, Christopher K., Bearson, Shawn M.D., Plastow, Graham S., Stothard, Paul, Guan, Le Luo
Format: Article
Language:English
Subjects:
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Animals
Bacterial diseases
Blood
Cation Transport Proteins - genetics
Foodborne Diseases - microbiology
Foodborne pathogens
Gene expression
Gene Expression Profiling
Gene Expression Regulation
Genome-Wide Association Study
Genomes
Host-Pathogen Interactions - genetics
Humanities and Social Sciences
Immune response
Infections
MicroRNAs - blood
MicroRNAs - genetics
miRNA
multidisciplinary
Pathogens
Reproducibility of Results
RNA, Messenger - blood
Salmonella
Salmonella Infections, Animal - genetics
Salmonella Infections, Animal - immunology
Science
Sus scrofa - genetics
Sus scrofa - microbiology
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Summary:To understand the role of miRNAs in regulating genes involved in host response to bacterial infection and shedding of foodborne pathogens, a systematic profiling of miRNAs and mRNAs from the whole blood of pigs upon Salmonella challenge was performed. A total of 62 miRNAs were differentially expressed post infection (false discovery rate
ISSN:2045-2322
2045-2322
DOI:10.1038/srep12620