Sparse whole-genome sequencing identifies two loci for major depressive disorder

• Published in: Nature (London) 2015-07, Vol.523 (7562), p.588-591
• Main Authors: Cai, Na, Bigdeli, Tim B, Kretzschmar, Warren, Li, Yihan, Liang, Jieqin, Song, Li, Hu, Jingchu
• Format: Article
• Language: English
• Subjects: 45; 45/43; 631/208/205/2138; Adolescent; Adult; Analysis; Asian People - genetics; Causes of; China; Chromosomes, Human, Pair 10 - genetics; Cohort Studies; Depressive Disorder - genetics; Depressive Disorder, Major - genetics; DNA sequencing; Female; Genetic aspects; Genetic Loci - genetics; Genetic susceptibility; Genome, Human - genetics; Genome-Wide Association Study; Health aspects; Humanities and Social Sciences; Humans; Inorganic Pyrophosphatase - genetics; Introns - genetics; letter; Major depressive disorder; Methods; Middle Aged; multidisciplinary; Nucleotide sequencing; Quantitative trait loci; Science; Sequence Analysis, DNA; Sirtuin 1 - genetics; Young Adult
• ISSN: 0028-0836; 1476-4687
• DOI: 10.1038/nature14659

Genomic analysis of 5,303 Chinese women with recurrent major depressive disorder (MDD) enables the identification and replication of two genome-wide significant loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene; the other in an intron of the LHPP gene. Genetic risk factors for depression This genomic analysis of more than 5,000 Chinese women with recurrent major depressive disorder (MDD) has identified and replicated two genome-wide significant loci contributing to risk of MDD on chromosome 10. One is near the sirtuin1 ( SIRT1 ) gene, and the other is in an intron of the phospholysine phosphohistidine inorganic pyrophosphate phosphatase ( LHPP ) gene. The authors suggest that the association close to SIRT1 may implicate abnormalities in mitochondria as risk factors for the disease. Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide 1 , poses a major challenge to genetic analysis. To date, no robustly replicated genetic loci have been identified 2 , despite analysis of more than 9,000 cases 3 . Here, using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, we identified, and subsequently replicated in an independent sample, two loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene ( P  = 2.53 × 10 −10 ), the other in an intron of the LHPP gene ( P = 6.45 × 10 −12 ). Analysis of 4,509 cases with a severe subtype of MDD, melancholia, yielded an increased genetic signal at the SIRT1 locus. We attribute our success to the recruitment of relatively homogeneous cases with severe illness.