Circulating Levels of Carboxy‐Methyl‐Lysine (CML) Are Associated With Hip Fracture Risk: The Cardiovascular Health Study

ABSTRACT Advanced glycation end products (AGE) in bone tissue are associated with impaired biomechanical properties and increased fracture risk. Here we examine whether serum levels of the AGE carboxy‐methyl‐lysine (CML) are associated with risk of hip fracture. We followed 3373 participants from th...

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Published in:Journal of bone and mineral research 2014-05, Vol.29 (5), p.1061-1066
Main Authors: Barzilay, Joshua I, Bůžková, Petra, Zieman, Susan J, Kizer, Jorge R, Djoussé, Luc, Ix, Joachim H, Tracy, Russell P, Siscovick, David S, Cauley, Jane A, Mukamal, Kenneth J
Format: Article
Language:English
Subjects:
Age Factors
Aged
BONE MINERAL DENSITY
BONE QUALITY
CARBOXY‐METHYL‐LYSINE
CARDIOVASCULAR HEALTH STUDY
Female
Follow-Up Studies
Glycation End Products, Advanced - blood
HIP FRACTURE RISK
Hip Fractures - blood
Hip Fractures - epidemiology
Humans
Incidence
Lysine - analogs & derivatives
Lysine - blood
Male
Prospective Studies
Retrospective Studies
Risk Factors
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Summary:ABSTRACT Advanced glycation end products (AGE) in bone tissue are associated with impaired biomechanical properties and increased fracture risk. Here we examine whether serum levels of the AGE carboxy‐methyl‐lysine (CML) are associated with risk of hip fracture. We followed 3373 participants from the Cardiovascular Health Study (age 78 years; range, 68–102 years; 39.8% male) for a median of 9.22 years (range, 0.01–12.07 years). Rates of incident hip fracture were calculated by quartiles of baseline CML levels, and hazard ratios were adjusted for covariates associated with hip fracture risk. A subcohort of 1315 participants had bone mineral density (BMD) measurement. There were 348 hip fractures during follow‐up, with incidence rates of hip fracture by CML quartiles of 0.94, 1.34, 1.18, and 1.69 per 100 participant‐years. The unadjusted hazard ratio of hip fracture increased with each 1 SD increase (189 ng/mL) of CML level (hazard ratio, 1.27; 95% confidence interval [CI], 1.16–1.40]; p 
ISSN:0884-0431
1523-4681
DOI:10.1002/jbmr.2123