Dynamic aberrant NF-κB spurs tumorigenesis: A new model encompassing the microenvironment

Highlights • During inflammation, cytokines induce a sequential activation of different cell types. • Malignant cells can express gene cohorts from different stages of the inflammatory cascade. • Dysregulation of NF-κB enables combining programs of stem cells with differentiated cells. • The result...

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Bibliographic Details
Published in:Cytokine & growth factor reviews 2015-08, Vol.26 (4), p.389-403
Main Authors: Vlahopoulos, Spiros A, Cen, Osman, Hengen, Nina, Agan, James, Moschovi, Maria, Critselis, Elena, Adamaki, Maria, Bacopoulou, Flora, Copland, John A, Boldogh, Istvan, Karin, Michael, Chrousos, George P
Format: Article
Language:English
Subjects:
Advanced Basic Science
Cancer
Homeostasis
Immunity
Inflammation
Nuclear Factor kappa B
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Summary:Highlights • During inflammation, cytokines induce a sequential activation of different cell types. • Malignant cells can express gene cohorts from different stages of the inflammatory cascade. • Dysregulation of NF-κB enables combining programs of stem cells with differentiated cells. • The result is an aberrant interaction with the host tissue and the immune system. • Disruption of essential mediators of homeostasis has far-ranging effects on the organism.
ISSN:1359-6101
1879-0305
DOI:10.1016/j.cytogfr.2015.06.001