Molecular cytogenetic studies characterizing a novel complex karyotype with an uncommon 5q22 deletion in childhood acute myeloid leukemia

• Published in: Molecular cytogenetics 2015-08, Vol.8 (1), p.62, Article 62
• Main Authors: de Figueiredo, Amanda Faria, Capela de Matos, Roberto Rodrigues, Othman, Moneeb A K, Liehr, Thomas, da Costa, Elaine Sobral, Land, Marcelo Geradin Poirot, Ribeiro, Raul C, Abdelhay, Eliana, Silva, Maria Luiza Macedo
• Format: Article
• Language: English
• Subjects: Analysis; Case Report; Case studies; Chromosomes; Medical colleges; Pediatrics
• ISSN: 1755-8166; 1755-8166
• DOI: 10.1186/s13039-015-0167-y

Deletions in the long arm of chromosome 5 or loss of the whole chromosome are rare in childhood Acute Myeloid Leukemia (AML) patients. It is also unknown if the wide variety of breakpoints have diverging implications in the patient's outcome. Despite -5/5q- abnormalities have usually been described as a poor prognostic feature, however, the low frequency of -5/5q- in pediatric AML patients limits a full knowledge about this cytogenetic and clinical category, which is an intriguing factor for further research and new findings. Here, we report an AML child showing an uncommon deletion in 5q associated with 2 new abnormalities involving chromosome 2 within a complex karyotype well-characterized by several molecular cytogenetic approaches. Our work stimulates upcoming studies with more detailed descriptions about 5q abnormalities to better define its role in the stratification risk of such cytogenetic subgroup in childhood AML.