What single-cell stimulation has told us about neural coding

In recent years, single-cell stimulation experiments have resulted in substantial progress towards directly linking single-cell activity to movement and sensation. Recent advances in electrical recording and stimulation techniques have enabled control of single neuron spiking in vivo and have contri...

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Bibliographic Details
Published in:Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2015-09, Vol.370 (1677), p.20140204-20140204
Main Authors: Doron, Guy, Brecht, Michael
Format: Article
Language:English
Subjects:
Animals
Brain - cytology
Brain - physiology
Electric Stimulation - methods
Evoked Potentials
Humans
Models, Neurological
Motor Control
Motor Cortex - cytology
Motor Cortex - physiology
Motor Neurons - physiology
Nanostimulation
Neurons - physiology
Optogenetics - methods
Patch Clamp
Review
Sensation
Sensory Receptor Cells - physiology
Single Neuron
Single-Cell Analysis - methods
Somatosensory Cortex - cytology
Somatosensory Cortex - physiology
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Summary:In recent years, single-cell stimulation experiments have resulted in substantial progress towards directly linking single-cell activity to movement and sensation. Recent advances in electrical recording and stimulation techniques have enabled control of single neuron spiking in vivo and have contributed to our understanding of neuronal coding schemes in the brain. Here, we review single neuron stimulation effects in different brain structures and how they vary with artificially inserted spike patterns. We briefly compare single neuron stimulation with other brain stimulation techniques. A key advantage of single neuron stimulation is the precise control of the evoked spiking patterns. Systematically varying spike patterns and measuring evoked movements and sensations enables ‘decoding’ of the single-cell spike patterns and provides insights into the readout mechanisms of sensory and motor cortical spikes.
ISSN:0962-8436
1471-2970
DOI:10.1098/rstb.2014.0204