Bufei Yishen granule combined with acupoint sticking improves pulmonary function and morphormetry in chronic obstructive pulmonary disease rats

The integrated therapy of Bufei Yishen granule and acupoint sticking has been used in the treatment of stable chronic obstructive pulmonary disease (COPD) clinically, with remarkable benefits. This study was initiated to observe the effects of the combination of Bufei Yishen granule and acupoint sti...

Full description

Saved in:
Bibliographic Details
Published in:BMC complementary and alternative medicine 2015-08, Vol.15 (1), p.266-266, Article 266
Main Authors: Tian, Yange, Li, Ya, Li, Jiansheng, Xie, Yang, Wang, Minghang, Dong, Yuqiong, Li, Linlin, Mao, Jing, Wang, Lili, Luo, Shan
Format: Article
Language:English
Subjects:
Acupuncture Points
aminophylline
animal models
Animals
cigarettes
complement
Drugs, Chinese Herbal - administration & dosage
histology
Humans
Lung - drug effects
Lung - pathology
Lung - physiopathology
lung function
lungs
Male
mitochondria
plethysmography
Pulmonary Disease, Chronic Obstructive - drug therapy
Pulmonary Disease, Chronic Obstructive - pathology
Pulmonary Disease, Chronic Obstructive - physiopathology
Rats
respiratory tract diseases
smoke
therapeutics
tidal volume
ultrastructure
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The integrated therapy of Bufei Yishen granule and acupoint sticking has been used in the treatment of stable chronic obstructive pulmonary disease (COPD) clinically, with remarkable benefits. This study was initiated to observe the effects of the combination of Bufei Yishen granule and acupoint sticking on pulmonary function and morphormetry in a COPD rat model. Rats were randomized into Control, Model, Bufei Yishen (BY), Acupoint sticking (AS), Bufei Yishen + Acupoint sticking (BY + AS) and aminophyline (APL) groups. COPD rats were duplicated by repeated cigarette smoke and bacterial exposures. The rats were treated with normal saline, Bufei Yishen granule, acupoint sticking, Bufei Yishen + Acupoint sticking and aminophylline, respectively, from week 9 through 20. Pulmonary function was measured by using a whole body plethysmograph every 4 weeks. The rats were sacrificed at the end of week 20, and lung tissue histology and ultrastructure was observed under light and electron microscopes. The pulmonary function, including tidal volume (VT), peak expiratory flow (PEF) and expiratory flow at 50 % tidal volume (EF50), was markedly decreased from week 8 in COPD rats (P 
ISSN:1472-6882
1472-6882
DOI:10.1186/s12906-015-0787-0