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Bufei Yishen granule combined with acupoint sticking improves pulmonary function and morphormetry in chronic obstructive pulmonary disease rats
The integrated therapy of Bufei Yishen granule and acupoint sticking has been used in the treatment of stable chronic obstructive pulmonary disease (COPD) clinically, with remarkable benefits. This study was initiated to observe the effects of the combination of Bufei Yishen granule and acupoint sti...
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| Published in: | BMC complementary and alternative medicine 2015-08, Vol.15 (1), p.266-266, Article 266 |
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| creator | Tian, Yange Li, Ya Li, Jiansheng Xie, Yang Wang, Minghang Dong, Yuqiong Li, Linlin Mao, Jing Wang, Lili Luo, Shan |
| description | The integrated therapy of Bufei Yishen granule and acupoint sticking has been used in the treatment of stable chronic obstructive pulmonary disease (COPD) clinically, with remarkable benefits. This study was initiated to observe the effects of the combination of Bufei Yishen granule and acupoint sticking on pulmonary function and morphormetry in a COPD rat model.
Rats were randomized into Control, Model, Bufei Yishen (BY), Acupoint sticking (AS), Bufei Yishen + Acupoint sticking (BY + AS) and aminophyline (APL) groups. COPD rats were duplicated by repeated cigarette smoke and bacterial exposures. The rats were treated with normal saline, Bufei Yishen granule, acupoint sticking, Bufei Yishen + Acupoint sticking and aminophylline, respectively, from week 9 through 20. Pulmonary function was measured by using a whole body plethysmograph every 4 weeks. The rats were sacrificed at the end of week 20, and lung tissue histology and ultrastructure was observed under light and electron microscopes.
The pulmonary function, including tidal volume (VT), peak expiratory flow (PEF) and expiratory flow at 50 % tidal volume (EF50), was markedly decreased from week 8 in COPD rats (P |
| doi_str_mv | 10.1186/s12906-015-0787-0 |
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| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4529718</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A541440304</galeid><sourcerecordid>A541440304</sourcerecordid><originalsourceid>FETCH-LOGICAL-c558t-426a4d6d452b474c7368f637fd29cea8c9175b964dbeb78448ef9d8bc54132263</originalsourceid><addsrcrecordid>eNqFks-K1TAUxosozjj6AG4kIIibjkmaNulGmBl0FAbc6MJVSNPT24xtUvPnik_hK5t67wz3iiBZJCS_78vhnK8onhN8Toho3gRCW9yUmNQl5oKX-EFxShinZSMEfXhwPimehHCLMeGCsMfFCW1oXVFGTotfl2kAg76aMIJFG69smgBpN3fGQo9-mDgipdPijI0oRKO_GbtBZl6820JAS5pmZ5X_iYZkdTTOImV7NDu_jM7PEPOLsUiP3lmjketC9ClzWziQ9iaACoC8iuFp8WhQU4Bn-_2s-PL-3eerD-XNp-uPVxc3pa5rEUtGG8X6pmc17RhnmleNGJqKDz1tNSihW8Lrrm1Y30HHBWMChrYXna4ZqShtqrPi7c53Sd0MvQYbvZrk4s2cS5JOGXn8Ys0oN24r848tJyIbvN4bePc9QYhyNkHDNCkLLgVJOa0IyV-x_6KE4zyMXFmd0Zd_obcueZs7kSmB89DJH8M9tVETSGMHl0vUq6m8yDaM4Qqv1Pk_qLx6mI12FgaT748Erw4EI6gpjsFNaR1rOAbJDtTeheBhuO8bwXJNptwlU-ZkyjWZEmfNi8OG3yvuolj9Bnvx4CU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780186164</pqid></control><display><type>article</type><title>Bufei Yishen granule combined with acupoint sticking improves pulmonary function and morphormetry in chronic obstructive pulmonary disease rats</title><source>PubMed Central</source><creator>Tian, Yange ; Li, Ya ; Li, Jiansheng ; Xie, Yang ; Wang, Minghang ; Dong, Yuqiong ; Li, Linlin ; Mao, Jing ; Wang, Lili ; Luo, Shan</creator><creatorcontrib>Tian, Yange ; Li, Ya ; Li, Jiansheng ; Xie, Yang ; Wang, Minghang ; Dong, Yuqiong ; Li, Linlin ; Mao, Jing ; Wang, Lili ; Luo, Shan</creatorcontrib><description>The integrated therapy of Bufei Yishen granule and acupoint sticking has been used in the treatment of stable chronic obstructive pulmonary disease (COPD) clinically, with remarkable benefits. This study was initiated to observe the effects of the combination of Bufei Yishen granule and acupoint sticking on pulmonary function and morphormetry in a COPD rat model.
Rats were randomized into Control, Model, Bufei Yishen (BY), Acupoint sticking (AS), Bufei Yishen + Acupoint sticking (BY + AS) and aminophyline (APL) groups. COPD rats were duplicated by repeated cigarette smoke and bacterial exposures. The rats were treated with normal saline, Bufei Yishen granule, acupoint sticking, Bufei Yishen + Acupoint sticking and aminophylline, respectively, from week 9 through 20. Pulmonary function was measured by using a whole body plethysmograph every 4 weeks. The rats were sacrificed at the end of week 20, and lung tissue histology and ultrastructure was observed under light and electron microscopes.
The pulmonary function, including tidal volume (VT), peak expiratory flow (PEF) and expiratory flow at 50 % tidal volume (EF50), was markedly decreased from week 8 in COPD rats (P < 0.05). At week 20, VT, PEF and EF50 were significantly lower in Model group (P < 0.05). Compared with Model group, VT, PEF and EF50 were higher in BY and BY + AS groups (P < 0.05), and EF50 was higher in AS group, while VT was higher in APL group (P < 0.05). Markedly histological and ultrastructural changes, including respiratory membrane thickening, volume density of lamellar corpuscle decreasing, mitochondria reducing in type II alveolar cell, were found in COPD rats and were alleviated in the treated groups, especially in BY and BY + AS groups.
Bufei Yishen granule and acupoint sticking can improve pulmonary function and lung pathological impairment in COPD rats, the curative effect of the combination is better than acupoint sticking or aminophylline only.</description><identifier>ISSN: 1472-6882</identifier><identifier>EISSN: 1472-6882</identifier><identifier>DOI: 10.1186/s12906-015-0787-0</identifier><identifier>PMID: 26253241</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Acupuncture Points ; aminophylline ; animal models ; Animals ; cigarettes ; complement ; Drugs, Chinese Herbal - administration & dosage ; histology ; Humans ; Lung - drug effects ; Lung - pathology ; Lung - physiopathology ; lung function ; lungs ; Male ; mitochondria ; plethysmography ; Pulmonary Disease, Chronic Obstructive - drug therapy ; Pulmonary Disease, Chronic Obstructive - pathology ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Rats ; respiratory tract diseases ; smoke ; therapeutics ; tidal volume ; ultrastructure</subject><ispartof>BMC complementary and alternative medicine, 2015-08, Vol.15 (1), p.266-266, Article 266</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>Tian et al. 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-426a4d6d452b474c7368f637fd29cea8c9175b964dbeb78448ef9d8bc54132263</citedby><cites>FETCH-LOGICAL-c558t-426a4d6d452b474c7368f637fd29cea8c9175b964dbeb78448ef9d8bc54132263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529718/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529718/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26253241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tian, Yange</creatorcontrib><creatorcontrib>Li, Ya</creatorcontrib><creatorcontrib>Li, Jiansheng</creatorcontrib><creatorcontrib>Xie, Yang</creatorcontrib><creatorcontrib>Wang, Minghang</creatorcontrib><creatorcontrib>Dong, Yuqiong</creatorcontrib><creatorcontrib>Li, Linlin</creatorcontrib><creatorcontrib>Mao, Jing</creatorcontrib><creatorcontrib>Wang, Lili</creatorcontrib><creatorcontrib>Luo, Shan</creatorcontrib><title>Bufei Yishen granule combined with acupoint sticking improves pulmonary function and morphormetry in chronic obstructive pulmonary disease rats</title><title>BMC complementary and alternative medicine</title><addtitle>BMC Complement Altern Med</addtitle><description>The integrated therapy of Bufei Yishen granule and acupoint sticking has been used in the treatment of stable chronic obstructive pulmonary disease (COPD) clinically, with remarkable benefits. This study was initiated to observe the effects of the combination of Bufei Yishen granule and acupoint sticking on pulmonary function and morphormetry in a COPD rat model.
Rats were randomized into Control, Model, Bufei Yishen (BY), Acupoint sticking (AS), Bufei Yishen + Acupoint sticking (BY + AS) and aminophyline (APL) groups. COPD rats were duplicated by repeated cigarette smoke and bacterial exposures. The rats were treated with normal saline, Bufei Yishen granule, acupoint sticking, Bufei Yishen + Acupoint sticking and aminophylline, respectively, from week 9 through 20. Pulmonary function was measured by using a whole body plethysmograph every 4 weeks. The rats were sacrificed at the end of week 20, and lung tissue histology and ultrastructure was observed under light and electron microscopes.
The pulmonary function, including tidal volume (VT), peak expiratory flow (PEF) and expiratory flow at 50 % tidal volume (EF50), was markedly decreased from week 8 in COPD rats (P < 0.05). At week 20, VT, PEF and EF50 were significantly lower in Model group (P < 0.05). Compared with Model group, VT, PEF and EF50 were higher in BY and BY + AS groups (P < 0.05), and EF50 was higher in AS group, while VT was higher in APL group (P < 0.05). Markedly histological and ultrastructural changes, including respiratory membrane thickening, volume density of lamellar corpuscle decreasing, mitochondria reducing in type II alveolar cell, were found in COPD rats and were alleviated in the treated groups, especially in BY and BY + AS groups.
Bufei Yishen granule and acupoint sticking can improve pulmonary function and lung pathological impairment in COPD rats, the curative effect of the combination is better than acupoint sticking or aminophylline only.</description><subject>Acupuncture Points</subject><subject>aminophylline</subject><subject>animal models</subject><subject>Animals</subject><subject>cigarettes</subject><subject>complement</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>histology</subject><subject>Humans</subject><subject>Lung - drug effects</subject><subject>Lung - pathology</subject><subject>Lung - physiopathology</subject><subject>lung function</subject><subject>lungs</subject><subject>Male</subject><subject>mitochondria</subject><subject>plethysmography</subject><subject>Pulmonary Disease, Chronic Obstructive - drug therapy</subject><subject>Pulmonary Disease, Chronic Obstructive - pathology</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Rats</subject><subject>respiratory tract diseases</subject><subject>smoke</subject><subject>therapeutics</subject><subject>tidal volume</subject><subject>ultrastructure</subject><issn>1472-6882</issn><issn>1472-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqFks-K1TAUxosozjj6AG4kIIibjkmaNulGmBl0FAbc6MJVSNPT24xtUvPnik_hK5t67wz3iiBZJCS_78vhnK8onhN8Toho3gRCW9yUmNQl5oKX-EFxShinZSMEfXhwPimehHCLMeGCsMfFCW1oXVFGTotfl2kAg76aMIJFG69smgBpN3fGQo9-mDgipdPijI0oRKO_GbtBZl6820JAS5pmZ5X_iYZkdTTOImV7NDu_jM7PEPOLsUiP3lmjketC9ClzWziQ9iaACoC8iuFp8WhQU4Bn-_2s-PL-3eerD-XNp-uPVxc3pa5rEUtGG8X6pmc17RhnmleNGJqKDz1tNSihW8Lrrm1Y30HHBWMChrYXna4ZqShtqrPi7c53Sd0MvQYbvZrk4s2cS5JOGXn8Ys0oN24r848tJyIbvN4bePc9QYhyNkHDNCkLLgVJOa0IyV-x_6KE4zyMXFmd0Zd_obcueZs7kSmB89DJH8M9tVETSGMHl0vUq6m8yDaM4Qqv1Pk_qLx6mI12FgaT748Erw4EI6gpjsFNaR1rOAbJDtTeheBhuO8bwXJNptwlU-ZkyjWZEmfNi8OG3yvuolj9Bnvx4CU</recordid><startdate>20150808</startdate><enddate>20150808</enddate><creator>Tian, Yange</creator><creator>Li, Ya</creator><creator>Li, Jiansheng</creator><creator>Xie, Yang</creator><creator>Wang, Minghang</creator><creator>Dong, Yuqiong</creator><creator>Li, Linlin</creator><creator>Mao, Jing</creator><creator>Wang, Lili</creator><creator>Luo, Shan</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20150808</creationdate><title>Bufei Yishen granule combined with acupoint sticking improves pulmonary function and morphormetry in chronic obstructive pulmonary disease rats</title><author>Tian, Yange ; Li, Ya ; Li, Jiansheng ; Xie, Yang ; Wang, Minghang ; Dong, Yuqiong ; Li, Linlin ; Mao, Jing ; Wang, Lili ; Luo, Shan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c558t-426a4d6d452b474c7368f637fd29cea8c9175b964dbeb78448ef9d8bc54132263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acupuncture Points</topic><topic>aminophylline</topic><topic>animal models</topic><topic>Animals</topic><topic>cigarettes</topic><topic>complement</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>histology</topic><topic>Humans</topic><topic>Lung - drug effects</topic><topic>Lung - pathology</topic><topic>Lung - physiopathology</topic><topic>lung function</topic><topic>lungs</topic><topic>Male</topic><topic>mitochondria</topic><topic>plethysmography</topic><topic>Pulmonary Disease, Chronic Obstructive - drug therapy</topic><topic>Pulmonary Disease, Chronic Obstructive - pathology</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Rats</topic><topic>respiratory tract diseases</topic><topic>smoke</topic><topic>therapeutics</topic><topic>tidal volume</topic><topic>ultrastructure</topic><toplevel>online_resources</toplevel><creatorcontrib>Tian, Yange</creatorcontrib><creatorcontrib>Li, Ya</creatorcontrib><creatorcontrib>Li, Jiansheng</creatorcontrib><creatorcontrib>Xie, Yang</creatorcontrib><creatorcontrib>Wang, Minghang</creatorcontrib><creatorcontrib>Dong, Yuqiong</creatorcontrib><creatorcontrib>Li, Linlin</creatorcontrib><creatorcontrib>Mao, Jing</creatorcontrib><creatorcontrib>Wang, Lili</creatorcontrib><creatorcontrib>Luo, Shan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tian, Yange</au><au>Li, Ya</au><au>Li, Jiansheng</au><au>Xie, Yang</au><au>Wang, Minghang</au><au>Dong, Yuqiong</au><au>Li, Linlin</au><au>Mao, Jing</au><au>Wang, Lili</au><au>Luo, Shan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bufei Yishen granule combined with acupoint sticking improves pulmonary function and morphormetry in chronic obstructive pulmonary disease rats</atitle><jtitle>BMC complementary and alternative medicine</jtitle><addtitle>BMC Complement Altern Med</addtitle><date>2015-08-08</date><risdate>2015</risdate><volume>15</volume><issue>1</issue><spage>266</spage><epage>266</epage><pages>266-266</pages><artnum>266</artnum><issn>1472-6882</issn><eissn>1472-6882</eissn><abstract>The integrated therapy of Bufei Yishen granule and acupoint sticking has been used in the treatment of stable chronic obstructive pulmonary disease (COPD) clinically, with remarkable benefits. This study was initiated to observe the effects of the combination of Bufei Yishen granule and acupoint sticking on pulmonary function and morphormetry in a COPD rat model.
Rats were randomized into Control, Model, Bufei Yishen (BY), Acupoint sticking (AS), Bufei Yishen + Acupoint sticking (BY + AS) and aminophyline (APL) groups. COPD rats were duplicated by repeated cigarette smoke and bacterial exposures. The rats were treated with normal saline, Bufei Yishen granule, acupoint sticking, Bufei Yishen + Acupoint sticking and aminophylline, respectively, from week 9 through 20. Pulmonary function was measured by using a whole body plethysmograph every 4 weeks. The rats were sacrificed at the end of week 20, and lung tissue histology and ultrastructure was observed under light and electron microscopes.
The pulmonary function, including tidal volume (VT), peak expiratory flow (PEF) and expiratory flow at 50 % tidal volume (EF50), was markedly decreased from week 8 in COPD rats (P < 0.05). At week 20, VT, PEF and EF50 were significantly lower in Model group (P < 0.05). Compared with Model group, VT, PEF and EF50 were higher in BY and BY + AS groups (P < 0.05), and EF50 was higher in AS group, while VT was higher in APL group (P < 0.05). Markedly histological and ultrastructural changes, including respiratory membrane thickening, volume density of lamellar corpuscle decreasing, mitochondria reducing in type II alveolar cell, were found in COPD rats and were alleviated in the treated groups, especially in BY and BY + AS groups.
Bufei Yishen granule and acupoint sticking can improve pulmonary function and lung pathological impairment in COPD rats, the curative effect of the combination is better than acupoint sticking or aminophylline only.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26253241</pmid><doi>10.1186/s12906-015-0787-0</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acupuncture Points aminophylline animal models Animals cigarettes complement Drugs, Chinese Herbal - administration & dosage histology Humans Lung - drug effects Lung - pathology Lung - physiopathology lung function lungs Male mitochondria plethysmography Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - pathology Pulmonary Disease, Chronic Obstructive - physiopathology Rats respiratory tract diseases smoke therapeutics tidal volume ultrastructure |
| title | Bufei Yishen granule combined with acupoint sticking improves pulmonary function and morphormetry in chronic obstructive pulmonary disease rats |
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