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The essential roles of transition fibers in the context of cilia

Once thought of as a vestigial organelle, the primary cilium is now recognized as a signaling hub for key cellular pathways in vertebrate development. The recent renaissance in cilia studies significantly improved our understanding of how cilia form and function, but little is known about how ciliog...

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Bibliographic Details
Published in:Current opinion in cell biology 2015-08, Vol.35, p.98-105
Main Authors: Wei, Qing, Ling, Kun, Hu, Jinghua
Format: Article
Language:English
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Summary:Once thought of as a vestigial organelle, the primary cilium is now recognized as a signaling hub for key cellular pathways in vertebrate development. The recent renaissance in cilia studies significantly improved our understanding of how cilia form and function, but little is known about how ciliogenesis is initiated and how ciliary proteins enter cilia. These important ciliary events require transition fibers (TFs) that are positioned at the ciliary base as symmetric nine-bladed propeller fibrous structures. Up until recently, TFs have been the most underappreciated ciliary structures due to limited knowledge about their molecular composition and function. Here, we highlight recent advances in our understanding of TF composition and the indispensable roles of TFs in regulating the initiation of ciliogenesis and the selective import of ciliary proteins.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2015.04.015