Leukemia inhibitory factor receptor is structurally related to the IL‐6 signal transducer, gp130

Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin‐6 (IL‐6) although LIF and IL‐6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental...

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Bibliographic Details
Published in:The EMBO journal 1991-10, Vol.10 (10), p.2839-2848
Main Authors: Gearing, D.P., Thut, C.J., VandeBos, T., Gimpel, S.D., Delaney, P.B., King, J., Price, V., Cosman, D., Beckmann, M.P.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Antigens, CD
Base Sequence
Biological and medical sciences
Blotting, Northern
Cell receptors
Cell structures and functions
Cytokine Receptor gp130
DNA - genetics
Electrophoresis, Polyacrylamide Gel
Fundamental and applied biological sciences. Psychology
genes
Growth Inhibitors
Humans
interleukin 6
Interleukin-6 - metabolism
Leukemia Inhibitory Factor
Leukemia Inhibitory Factor Receptor alpha Subunit
Lymphokines - metabolism
Membrane Glycoproteins - chemistry
Membrane Glycoproteins - metabolism
Mice
Miscellaneous
Molecular and cellular biology
Molecular Sequence Data
Polymerase Chain Reaction
Receptors, Cytokine
Receptors, Immunologic - genetics
Receptors, Immunologic - metabolism
Receptors, OSM-LIF
Restriction Mapping
RNA, Messenger - genetics
Sequence Homology, Nucleic Acid
Signal Transduction
Substrate Specificity
Transcription, Genetic
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Description
Summary:Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin‐6 (IL‐6) although LIF and IL‐6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library. The LIF receptor is related to the gp130 ‘signal‐transducing’ component of the IL‐6 receptor and to the G‐CSF receptor, with the transmembrane and cytoplasmic regions of the LIF receptor and gp130 being most closely related. This relationship suggests a common signal transduction pathway for the two receptors and may help to explain similar biological effects of the two ligands. Murine cDNAs encoding soluble LIF receptors were isolated by cross‐hybridization and share 70% amino acid sequence identity to the human sequence.
ISSN:0261-4189
1460-2075
DOI:10.1002/j.1460-2075.1991.tb07833.x