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Leukemia inhibitory factor receptor is structurally related to the IL‐6 signal transducer, gp130
Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin‐6 (IL‐6) although LIF and IL‐6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental...
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| Published in: | The EMBO journal 1991-10, Vol.10 (10), p.2839-2848 |
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| container_end_page | 2848 |
| container_issue | 10 |
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| container_title | The EMBO journal |
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| creator | Gearing, D.P. Thut, C.J. VandeBos, T. Gimpel, S.D. Delaney, P.B. King, J. Price, V. Cosman, D. Beckmann, M.P. |
| description | Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin‐6 (IL‐6) although LIF and IL‐6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library. The LIF receptor is related to the gp130 ‘signal‐transducing’ component of the IL‐6 receptor and to the G‐CSF receptor, with the transmembrane and cytoplasmic regions of the LIF receptor and gp130 being most closely related. This relationship suggests a common signal transduction pathway for the two receptors and may help to explain similar biological effects of the two ligands. Murine cDNAs encoding soluble LIF receptors were isolated by cross‐hybridization and share 70% amino acid sequence identity to the human sequence. |
| doi_str_mv | 10.1002/j.1460-2075.1991.tb07833.x |
| format | article |
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A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library. The LIF receptor is related to the gp130 ‘signal‐transducing’ component of the IL‐6 receptor and to the G‐CSF receptor, with the transmembrane and cytoplasmic regions of the LIF receptor and gp130 being most closely related. This relationship suggests a common signal transduction pathway for the two receptors and may help to explain similar biological effects of the two ligands. Murine cDNAs encoding soluble LIF receptors were isolated by cross‐hybridization and share 70% amino acid sequence identity to the human sequence.</description><identifier>ISSN: 0261-4189</identifier><identifier>EISSN: 1460-2075</identifier><identifier>DOI: 10.1002/j.1460-2075.1991.tb07833.x</identifier><identifier>PMID: 1915266</identifier><identifier>CODEN: EMJODG</identifier><language>eng</language><publisher>London: Nature Publishing Group</publisher><subject>Amino Acid Sequence ; Animals ; Antigens, CD ; Base Sequence ; Biological and medical sciences ; Blotting, Northern ; Cell receptors ; Cell structures and functions ; Cytokine Receptor gp130 ; DNA - genetics ; Electrophoresis, Polyacrylamide Gel ; Fundamental and applied biological sciences. Psychology ; genes ; Growth Inhibitors ; Humans ; interleukin 6 ; Interleukin-6 - metabolism ; Leukemia Inhibitory Factor ; Leukemia Inhibitory Factor Receptor alpha Subunit ; Lymphokines - metabolism ; Membrane Glycoproteins - chemistry ; Membrane Glycoproteins - metabolism ; Mice ; Miscellaneous ; Molecular and cellular biology ; Molecular Sequence Data ; Polymerase Chain Reaction ; Receptors, Cytokine ; Receptors, Immunologic - genetics ; Receptors, Immunologic - metabolism ; Receptors, OSM-LIF ; Restriction Mapping ; RNA, Messenger - genetics ; Sequence Homology, Nucleic Acid ; Signal Transduction ; Substrate Specificity ; Transcription, Genetic</subject><ispartof>The EMBO journal, 1991-10, Vol.10 (10), p.2839-2848</ispartof><rights>1991 European Molecular Biology Organization</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6043-c7264c399b57ce83c3c91dd8d8ee63d0cdde68d99d68b832cfcba620e9f1a0cc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC452994/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC452994/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4996938$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1915266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gearing, D.P.</creatorcontrib><creatorcontrib>Thut, C.J.</creatorcontrib><creatorcontrib>VandeBos, T.</creatorcontrib><creatorcontrib>Gimpel, S.D.</creatorcontrib><creatorcontrib>Delaney, P.B.</creatorcontrib><creatorcontrib>King, J.</creatorcontrib><creatorcontrib>Price, V.</creatorcontrib><creatorcontrib>Cosman, D.</creatorcontrib><creatorcontrib>Beckmann, M.P.</creatorcontrib><title>Leukemia inhibitory factor receptor is structurally related to the IL‐6 signal transducer, gp130</title><title>The EMBO journal</title><addtitle>EMBO J</addtitle><description>Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin‐6 (IL‐6) although LIF and IL‐6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library. The LIF receptor is related to the gp130 ‘signal‐transducing’ component of the IL‐6 receptor and to the G‐CSF receptor, with the transmembrane and cytoplasmic regions of the LIF receptor and gp130 being most closely related. This relationship suggests a common signal transduction pathway for the two receptors and may help to explain similar biological effects of the two ligands. Murine cDNAs encoding soluble LIF receptors were isolated by cross‐hybridization and share 70% amino acid sequence identity to the human sequence.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antigens, CD</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cytokine Receptor gp130</subject><subject>DNA - genetics</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>genes</subject><subject>Growth Inhibitors</subject><subject>Humans</subject><subject>interleukin 6</subject><subject>Interleukin-6 - metabolism</subject><subject>Leukemia Inhibitory Factor</subject><subject>Leukemia Inhibitory Factor Receptor alpha Subunit</subject><subject>Lymphokines - metabolism</subject><subject>Membrane Glycoproteins - chemistry</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Mice</subject><subject>Miscellaneous</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>Polymerase Chain Reaction</subject><subject>Receptors, Cytokine</subject><subject>Receptors, Immunologic - genetics</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Receptors, OSM-LIF</subject><subject>Restriction Mapping</subject><subject>RNA, Messenger - genetics</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Signal Transduction</subject><subject>Substrate Specificity</subject><subject>Transcription, Genetic</subject><issn>0261-4189</issn><issn>1460-2075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNqVkc2O0zAUhS0EGsrAIyBZCLEiwX9xbCQWw2iAQUVsYG05107r4ibFTmC64xF4Rp6EhFYFVojVvdI5xzrXH0KPKCkpIezZpqRCkoKRuiqp1rQcGlIrzsubW2hxkm6jBWGSFoIqfRfdy3lDCKlUTc_QGdW0YlIuULP04ye_DRaHbh2aMPRpj1sL08TJg9_NS8g4D2mEYUw2xv0kRDt4h4ceD2uPr5c_vn2XOIdVZyMeku2yG8Gnp3i1o5zcR3daG7N_cJzn6OOrqw-Xb4rl-9fXlxfLAiQRvICaSQFc66aqwSsOHDR1TjnlveSOgHNeKqe1k6pRnEELjZWMeN1SSwD4OXpxeHc3NlvvwHdTlWh2KWxt2pveBvO30oW1WfVfjKiY1mLKPznmU_959Hkw25DBx2g734_Z1IwyKgT9p5FKokTFZ-PzgxFSn3Py7akMJWYmaTZmxmVmXGYmaY4kzc0UfvjnOb-jB3ST_vio2ww2ttO3Q8gnm9Baaq4m28XB9jVEv_-PAubq3cu3v3b-EwTdvx4</recordid><startdate>199110</startdate><enddate>199110</enddate><creator>Gearing, D.P.</creator><creator>Thut, C.J.</creator><creator>VandeBos, T.</creator><creator>Gimpel, S.D.</creator><creator>Delaney, P.B.</creator><creator>King, J.</creator><creator>Price, V.</creator><creator>Cosman, D.</creator><creator>Beckmann, M.P.</creator><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T3</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M81</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199110</creationdate><title>Leukemia inhibitory factor receptor is structurally related to the IL‐6 signal transducer, gp130</title><author>Gearing, D.P. ; Thut, C.J. ; VandeBos, T. ; Gimpel, S.D. ; Delaney, P.B. ; King, J. ; Price, V. ; Cosman, D. ; Beckmann, M.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6043-c7264c399b57ce83c3c91dd8d8ee63d0cdde68d99d68b832cfcba620e9f1a0cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antigens, CD</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Cytokine Receptor gp130</topic><topic>DNA - genetics</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>genes</topic><topic>Growth Inhibitors</topic><topic>Humans</topic><topic>interleukin 6</topic><topic>Interleukin-6 - metabolism</topic><topic>Leukemia Inhibitory Factor</topic><topic>Leukemia Inhibitory Factor Receptor alpha Subunit</topic><topic>Lymphokines - metabolism</topic><topic>Membrane Glycoproteins - chemistry</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Mice</topic><topic>Miscellaneous</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Polymerase Chain Reaction</topic><topic>Receptors, Cytokine</topic><topic>Receptors, Immunologic - genetics</topic><topic>Receptors, Immunologic - metabolism</topic><topic>Receptors, OSM-LIF</topic><topic>Restriction Mapping</topic><topic>RNA, Messenger - genetics</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Signal Transduction</topic><topic>Substrate Specificity</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gearing, D.P.</creatorcontrib><creatorcontrib>Thut, C.J.</creatorcontrib><creatorcontrib>VandeBos, T.</creatorcontrib><creatorcontrib>Gimpel, S.D.</creatorcontrib><creatorcontrib>Delaney, P.B.</creatorcontrib><creatorcontrib>King, J.</creatorcontrib><creatorcontrib>Price, V.</creatorcontrib><creatorcontrib>Cosman, D.</creatorcontrib><creatorcontrib>Beckmann, M.P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Human Genome Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The EMBO journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gearing, D.P.</au><au>Thut, C.J.</au><au>VandeBos, T.</au><au>Gimpel, S.D.</au><au>Delaney, P.B.</au><au>King, J.</au><au>Price, V.</au><au>Cosman, D.</au><au>Beckmann, M.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leukemia inhibitory factor receptor is structurally related to the IL‐6 signal transducer, gp130</atitle><jtitle>The EMBO journal</jtitle><addtitle>EMBO J</addtitle><date>1991-10</date><risdate>1991</risdate><volume>10</volume><issue>10</issue><spage>2839</spage><epage>2848</epage><pages>2839-2848</pages><issn>0261-4189</issn><eissn>1460-2075</eissn><coden>EMJODG</coden><abstract>Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin‐6 (IL‐6) although LIF and IL‐6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library. The LIF receptor is related to the gp130 ‘signal‐transducing’ component of the IL‐6 receptor and to the G‐CSF receptor, with the transmembrane and cytoplasmic regions of the LIF receptor and gp130 being most closely related. This relationship suggests a common signal transduction pathway for the two receptors and may help to explain similar biological effects of the two ligands. Murine cDNAs encoding soluble LIF receptors were isolated by cross‐hybridization and share 70% amino acid sequence identity to the human sequence.</abstract><cop>London</cop><pub>Nature Publishing Group</pub><pmid>1915266</pmid><doi>10.1002/j.1460-2075.1991.tb07833.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0261-4189 |
| ispartof | The EMBO journal, 1991-10, Vol.10 (10), p.2839-2848 |
| issn | 0261-4189 1460-2075 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_452994 |
| source | PubMed Central |
| subjects | Amino Acid Sequence Animals Antigens, CD Base Sequence Biological and medical sciences Blotting, Northern Cell receptors Cell structures and functions Cytokine Receptor gp130 DNA - genetics Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology genes Growth Inhibitors Humans interleukin 6 Interleukin-6 - metabolism Leukemia Inhibitory Factor Leukemia Inhibitory Factor Receptor alpha Subunit Lymphokines - metabolism Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Mice Miscellaneous Molecular and cellular biology Molecular Sequence Data Polymerase Chain Reaction Receptors, Cytokine Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Receptors, OSM-LIF Restriction Mapping RNA, Messenger - genetics Sequence Homology, Nucleic Acid Signal Transduction Substrate Specificity Transcription, Genetic |
| title | Leukemia inhibitory factor receptor is structurally related to the IL‐6 signal transducer, gp130 |
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