Paclitaxel-induced lung injury and its amelioration by parecoxib sodium

To investigate the mechanism of paclitaxel-induced lung injury and its amelioration by parecoxib sodium. In this study, rats were randomly divided into: the control group (Con); the paclitaxel chemotherapy group (Pac); the paclitaxel+ parecoxib sodium intervention group (Pac + Pare); and the parecox...

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Published in:Scientific reports 2015-08, Vol.5 (1), p.12977-12977, Article 12977
Main Authors: Liu, Wen-jie, Zhong, Zhong-jian, Cao, Long-hui, Li, Hui-ting, Zhang, Tian-hua, Lin, Wen-qian
Format: Article
Language:English
Subjects:
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Alveoli
Animals
Antineoplastic Agents, Phytogenic - toxicity
Blood Gas Analysis
Bronchoalveolar Lavage Fluid - chemistry
Bronchoalveolar Lavage Fluid - cytology
Chemotherapy
Claudin-4 - metabolism
Cyclooxygenase 2 - metabolism
Cyclooxygenase 2 Inhibitors - pharmacology
Cyclooxygenase-2
Cytokines
Cytokines - analysis
Female
Humanities and Social Sciences
Inflammation
Intercellular adhesion molecule 1
Intercellular Adhesion Molecule-1 - metabolism
Isoxazoles - pharmacology
Leukocytes - cytology
Leukocytes - metabolism
Lung - metabolism
Lung - pathology
Lung Injury - etiology
Lung Injury - metabolism
Lung Injury - pathology
Lungs
Membrane permeability
multidisciplinary
Paclitaxel
Paclitaxel - toxicity
Permeability
Permeability - drug effects
Rats
Rats, Wistar
Rodents
Science
Sodium
Ventilation
Zonula occludens-1 protein
Zonula Occludens-1 Protein - metabolism
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Summary:To investigate the mechanism of paclitaxel-induced lung injury and its amelioration by parecoxib sodium. In this study, rats were randomly divided into: the control group (Con); the paclitaxel chemotherapy group (Pac); the paclitaxel+ parecoxib sodium intervention group (Pac + Pare); and the parecoxib sodium group (Pare). We observed changes in alveolar ventilation function, alveolar-capillary membrane permeability, lung tissue pathology and measured the levels of inflammatory cytokines and cyclooxygenase-2 (Cox-2) in lung tissue, the expression of tight junction proteins (Zo-1 and Claudin-4). Compared with the Con group, the lung tissue of the Pac group showed significantly increased expression of Cox-2 protein (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep12977