Agranulocytosis induced by vancomycin in an ESRD patient on CAPD

Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients. We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during tr...

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Bibliographic Details
Published in:The Korean journal of internal medicine 2004-03, Vol.19 (1), p.58-61
Main Authors: Jo, Young-Il, Yoon, Jae-Ho, Shin, Sang-Youl, Chang, Won-Chul, Kim, Byung-Kook, Jin, Choon-Jo, Song, Jong-Oh
Format: Article
Language:English
Subjects:
Aged
Agranulocytosis - chemically induced
Agranulocytosis - drug therapy
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Case Report
Catheters, Indwelling - microbiology
Granulocyte Colony-Stimulating Factor - therapeutic use
Humans
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - therapy
Male
Peritoneal Dialysis, Continuous Ambulatory
Staphylococcal Infections - drug therapy
Vancomycin - adverse effects
Vancomycin - therapeutic use
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Summary:Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients. We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia. The agranulocytosis was rapidly resolved by granulocyte colony-stimulating factor (G-CSF) therapy and by the discontinuation of vancomycin.
ISSN:1226-3303
2005-6648
DOI:10.3904/kjim.2004.19.1.58