Successful treatment with ganciclovir for cytomegalovirus duodenitis following allogenic bone marrow transplantation

• Published in: The Korean journal of internal medicine 1999, Vol.14 (1), p.91-94
• Main Authors: Ahn, J H, Lee, J H, Lee, K H, Kim, W K, Lee, J S, Bahng, H, Jung, H Y, Kim, Y S, Kim, O, Kim, S H
• Format: Article
• Language: English
• Subjects: Adult; Antiviral Agents - therapeutic use; Bone Marrow Transplantation - adverse effects; Case Report; Cytomegalovirus Infections - diagnosis; Cytomegalovirus Infections - drug therapy; Cytomegalovirus Infections - etiology; Duodenitis - diagnosis; Duodenitis - drug therapy; Duodenitis - etiology; Ganciclovir - therapeutic use; Humans; Male; Transplantation, Homologous
• ISSN: 1226-3303; 2005-6648
• DOI: 10.3904/kjim.1999.14.1.91

Cytomegalovirus(CMV) disease is a major cause of morbidity and mortality in immunocompromised patients. CMV enteritis should be considered when nausea and vomiting continue 3 to 4 weeks after bone marrow transplantation(BMT). The treatment of CMV enteritis is not well established. We report a CMV duodenitis patient following allogenic bone marrow transplantation. The patient had prolonged nausea and vomiting for 5 weeks after bone marrow transplantation and CMV duodenitis was diagnosed by the gastroduodenoscopic mucosal biopsy which showed cytomegalic cells. Ganciclovir treatment for 3 weeks resulted in the resolution of symptoms and promoted healing of the lesion. The patient was free of CMV infection until 288 days after allogenic BMT without maintenance ganciclovir treatment.