Activation of the antigen presentation function of mononuclear phagocyte populations associated with the basilar membrane of the cochlea after acoustic overstimulation

Highlights • Diverse macrophage populations reside beneath the basilar membrane of the cochlea. • Monocytes undergo a time-dependent transformation into macrophages after acoustic overstimulation. • Acoustic overstimulation induces the upregulation of antigen-presenting proteins in the mononuclear p...

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Bibliographic Details
Published in:Neuroscience 2015-09, Vol.303, p.1-15
Main Authors: Yang, W, Vethanayagam, R.R, Dong, Y, Cai, Q, Hu, B.H
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Animals
antigen
Antigens - immunology
Basilar Membrane - cytology
Basilar Membrane - immunology
Basilar Membrane - metabolism
CD4-Positive T-Lymphocytes - immunology
cochlea
Female
Genes, MHC Class II
immunity
macrophage
Macrophages - immunology
Macrophages - metabolism
Male
MHC II
Mice, Inbred C57BL
Monocytes - immunology
Monocytes - metabolism
Mononuclear Phagocyte System - immunology
Mononuclear Phagocyte System - metabolism
Neurology
noise
Noise - adverse effects
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Summary:Highlights • Diverse macrophage populations reside beneath the basilar membrane of the cochlea. • Monocytes undergo a time-dependent transformation into macrophages after acoustic overstimulation. • Acoustic overstimulation induces the upregulation of antigen-presenting proteins in the mononuclear phagocytes. • CD4+ T cells participate in antigen-presenting activity in response to acoustic overstimulation. • Activation of antigen-presenting function is an immune cell response to acoustic overstimulation.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.05.081