VSIG4 is highly expressed and correlated with poor prognosis of high-grade glioma patients

The high-grade glioma (HGG) remains as the greatest challenge for cancer management worldwide. Identification of novel therapeutics and diagnostic method is in urgent need. The V-set and immunoglobulin domain-containing protein 4 (VSIG4) is a complement receptor for C3b/iC3b and inhibits cytotoxic T...

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Published in:American journal of translational research 2015-01, Vol.7 (6), p.1172-1180
Main Authors: Xu, Tao, Jiang, Ying, Yan, Yong, Wang, Hongxiang, Lu, Chengyin, Xu, Hanchong, Li, Weiqing, Fu, Da, Lu, Yicheng, Chen, Juxiang
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Language:English
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Summary:The high-grade glioma (HGG) remains as the greatest challenge for cancer management worldwide. Identification of novel therapeutics and diagnostic method is in urgent need. The V-set and immunoglobulin domain-containing protein 4 (VSIG4) is a complement receptor for C3b/iC3b and inhibits cytotoxic T lymphocytes activation, which may play important roles in glioma oncogenesis. In this study, we performed immunohistochemistry in tissue microarray to determine the expression of VSIG4 in malignant glioma and normal brain. We then applied univariate and multivariate analyses to evaluate the expression of VSIG4 and correlated with prognosis of glioma patients. We have shown that VSIG4 was significantly elevated in high-grade glioma compared with those of normal brain tissues (P
ISSN:1943-8141
1943-8141