Insights into the roles of hnRNP A2/B1 and AXL in non-small cell lung cancer

Lung cancer has long been one of the most serious types of malignant tumor, and is associated with high incidence and mortality rates. Despite advancements in the comprehensive treatment of the disease, particularly with targeted therapeutic agents, there has been little improvement in the 5-year su...

Full description

Saved in:
Bibliographic Details
Published in:Oncology letters 2015-09, Vol.10 (3), p.1677-1685
Main Authors: QU, XIAO-HAN, LIU, JIN-LU, ZHONG, XIN-WEN, LI, XI, ZHANG, QI-GANG
Format: Article
Language:English
Subjects:
Age
AXL receptor tyrosine kinase
Classification
Confidence intervals
Development and progression
Ethanol
Gender
Gene expression
Genetic aspects
Health aspects
heterogeneous nuclear ribonucleoprotein A2/B1
Kinases
Lung cancer
Lung cancer, Non-small cell
Medical prognosis
Metastasis
Mortality
non-small cell lung cancer
Oncology
Prognosis
Proteins
Ribonucleoproteins
Signal transduction
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lung cancer has long been one of the most serious types of malignant tumor, and is associated with high incidence and mortality rates. Despite advancements in the comprehensive treatment of the disease, particularly with targeted therapeutic agents, there has been little improvement in the 5-year survival rates of patients. One of the leading causes of mortality in lung cancer is the lack of effective early diagnostic criteria. On this basis, the present study aimed to identify an index with potential in the early diagnosis and prognosis of lung cancer. The current study determined the expression of heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 and AXL proteins in non-small cell lung cancer (NSCLC) tumor samples, and performed prognostic analysis of the collected clinical data to identify any association. In addition, RNA interference was performed to silence the expression of hnRNP A2/B1, allowing evaluation of its molecular and cellular functions, and determination of the mechanism of hnRNP A2/B1 in NSCLC by means of AXL mediation. It was identified that the positive expression rate of hnRNP A2/B1 and AXL proteins were significantly higher in NSCLC compared with paracancerous lung tissues (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2015.3457