Dimensionality of Rolled-up Nanomembranes Controls Neural Stem Cell Migration Mechanism

We employ glass microtube structures fabricated by rolled-up nanotechnology to infer the influence of scaffold dimensionality and cell confinement on neural stem cell (NSC) migration. Thereby, we observe a pronounced morphology change that marks a reversible mesenchymal to amoeboid migration mode tr...

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Bibliographic Details
Published in:Nano letters 2015-08, Vol.15 (8), p.5530-5538
Main Authors: Koch, Britta, Meyer, Anne K, Helbig, Linda, Harazim, Stefan M, Storch, Alexander, Sanchez, Samuel, Schmidt, Oliver G
Format: Article
Language:English
Subjects:
Animals
Biotechnology
Cell Line
Cell Movement
Confinement
Glass - chemistry
Letter
Membranes, Artificial
Mice
Migration
Nanostructure
Nanostructures - chemistry
Nanostructures - ultrastructure
Nanotechnology
Neural Stem Cells - cytology
Scaffolds
Stem cells
Tissue Scaffolds - chemistry
Topography
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Summary:We employ glass microtube structures fabricated by rolled-up nanotechnology to infer the influence of scaffold dimensionality and cell confinement on neural stem cell (NSC) migration. Thereby, we observe a pronounced morphology change that marks a reversible mesenchymal to amoeboid migration mode transition. Space restrictions preset by the diameter of nanomembrane topography modify the cell shape toward characteristics found in living tissue. We demonstrate the importance of substrate dimensionality for the migration mode of NSCs and thereby define rolled-up nanomembranes as the ultimate tool for single-cell migration studies.
ISSN:1530-6984
1530-6992
DOI:10.1021/acs.nanolett.5b02099