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Immunogenicity of the Bivalent Oral Cholera Vaccine Shanchol in Haitian Adults With HIV Infection
We evaluated immune responses following bivalent oral cholera vaccination (Shanchol [Shantha Biotechnics]; BivWC) in a cohort of 25 human immunodeficiency virus (HIV)-infected adults in Haiti. Compared with adults without HIV infection, vaccination in HI V-infected individuals resulted in lower vibr...
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| Published in: | The Journal of infectious diseases 2015-09, Vol.212 (5), p.779-783 |
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| cited_by | cdi_FETCH-LOGICAL-c442t-c895551dab6bd826f69bece455e280c19965ba3b387415f1741425efce16e9673 |
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| cites | cdi_FETCH-LOGICAL-c442t-c895551dab6bd826f69bece455e280c19965ba3b387415f1741425efce16e9673 |
| container_end_page | 783 |
| container_issue | 5 |
| container_start_page | 779 |
| container_title | The Journal of infectious diseases |
| container_volume | 212 |
| creator | Ivers, Louise Charles, Richelle C. Hilaire, Isabelle J. Mayo-Smith, Leslie M. Teng, Jessica E. Jerome, J. Gregory Rychert, Jenna LaRocque, Regina C. Xu, Peng Kováč, Pavol Ryan, Edward T. Qadri, Firdausi Almazor, Charles P. Franke, Molly F. Harris, Jason B. |
| description | We evaluated immune responses following bivalent oral cholera vaccination (Shanchol [Shantha Biotechnics]; BivWC) in a cohort of 25 human immunodeficiency virus (HIV)-infected adults in Haiti. Compared with adults without HIV infection, vaccination in HI V-infected individuals resulted in lower vibriocidal responses against Vibrio cholerae 01, and there was a positive relationship between the CD4⁺ T-cell count and vibriocidal responses following vaccination. Nevertheless, seroconversion occurred at a rate of 65% against the Ogawa serotype and 74% against the Inaba serotype in adults with HIV infection. These results suggest that the vaccine retains substantial immunogenicity in adults with HIV infection and may benefit this population by protecting against cholera. |
| doi_str_mv | 10.1093/infdis/jiv108 |
| format | article |
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Gregory ; Rychert, Jenna ; LaRocque, Regina C. ; Xu, Peng ; Kováč, Pavol ; Ryan, Edward T. ; Qadri, Firdausi ; Almazor, Charles P. ; Franke, Molly F. ; Harris, Jason B.</creator><creatorcontrib>Ivers, Louise ; Charles, Richelle C. ; Hilaire, Isabelle J. ; Mayo-Smith, Leslie M. ; Teng, Jessica E. ; Jerome, J. Gregory ; Rychert, Jenna ; LaRocque, Regina C. ; Xu, Peng ; Kováč, Pavol ; Ryan, Edward T. ; Qadri, Firdausi ; Almazor, Charles P. ; Franke, Molly F. ; Harris, Jason B.</creatorcontrib><description>We evaluated immune responses following bivalent oral cholera vaccination (Shanchol [Shantha Biotechnics]; BivWC) in a cohort of 25 human immunodeficiency virus (HIV)-infected adults in Haiti. Compared with adults without HIV infection, vaccination in HI V-infected individuals resulted in lower vibriocidal responses against Vibrio cholerae 01, and there was a positive relationship between the CD4⁺ T-cell count and vibriocidal responses following vaccination. Nevertheless, seroconversion occurred at a rate of 65% against the Ogawa serotype and 74% against the Inaba serotype in adults with HIV infection. These results suggest that the vaccine retains substantial immunogenicity in adults with HIV infection and may benefit this population by protecting against cholera.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiv108</identifier><identifier>PMID: 25722294</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Administration, Oral ; Adult ; BACTERIA ; Blood Bactericidal Activity ; CD4 Lymphocyte Count ; Cholera - prevention & control ; Cholera Vaccines - administration & dosage ; Cholera Vaccines - immunology ; Cohort Studies ; Female ; Haiti ; HIV Infections - complications ; HIV Infections - immunology ; Humans ; Immunoglobulin A - blood ; Lentivirus ; Major and Brief Reports ; Male ; Microbial Viability ; Middle Aged ; Retroviridae ; Vibrio cholerae</subject><ispartof>The Journal of infectious diseases, 2015-09, Vol.212 (5), p.779-783</ispartof><rights>Copyright © 2015 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</rights><rights>The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: . 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-c895551dab6bd826f69bece455e280c19965ba3b387415f1741425efce16e9673</citedby><cites>FETCH-LOGICAL-c442t-c895551dab6bd826f69bece455e280c19965ba3b387415f1741425efce16e9673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25722294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ivers, Louise</creatorcontrib><creatorcontrib>Charles, Richelle C.</creatorcontrib><creatorcontrib>Hilaire, Isabelle J.</creatorcontrib><creatorcontrib>Mayo-Smith, Leslie M.</creatorcontrib><creatorcontrib>Teng, Jessica E.</creatorcontrib><creatorcontrib>Jerome, J. Gregory</creatorcontrib><creatorcontrib>Rychert, Jenna</creatorcontrib><creatorcontrib>LaRocque, Regina C.</creatorcontrib><creatorcontrib>Xu, Peng</creatorcontrib><creatorcontrib>Kováč, Pavol</creatorcontrib><creatorcontrib>Ryan, Edward T.</creatorcontrib><creatorcontrib>Qadri, Firdausi</creatorcontrib><creatorcontrib>Almazor, Charles P.</creatorcontrib><creatorcontrib>Franke, Molly F.</creatorcontrib><creatorcontrib>Harris, Jason B.</creatorcontrib><title>Immunogenicity of the Bivalent Oral Cholera Vaccine Shanchol in Haitian Adults With HIV Infection</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>We evaluated immune responses following bivalent oral cholera vaccination (Shanchol [Shantha Biotechnics]; BivWC) in a cohort of 25 human immunodeficiency virus (HIV)-infected adults in Haiti. 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These results suggest that the vaccine retains substantial immunogenicity in adults with HIV infection and may benefit this population by protecting against cholera.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>BACTERIA</subject><subject>Blood Bactericidal Activity</subject><subject>CD4 Lymphocyte Count</subject><subject>Cholera - prevention & control</subject><subject>Cholera Vaccines - administration & dosage</subject><subject>Cholera Vaccines - immunology</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Haiti</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - immunology</subject><subject>Humans</subject><subject>Immunoglobulin A - blood</subject><subject>Lentivirus</subject><subject>Major and Brief Reports</subject><subject>Male</subject><subject>Microbial Viability</subject><subject>Middle Aged</subject><subject>Retroviridae</subject><subject>Vibrio cholerae</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNkc1v1DAQxS0EotvCkSPIRy6h_k58QSoryq5UqQegHC3HmTReJXaJnZX632OUsoIblxlp5qenN_MQekPJB0o0v_Sh73y6PPgjJc0ztKGS15VSlD9HG0IYq2ij9Rk6T-lACBFc1S_RGZM1Y0yLDbL7aVpCvIfgnc-POPY4D4A_-aMdIWR8O9sRb4c4wmzxnXXOB8BfBxtcmWEf8M767G3AV90y5oR_-Dzg3f4O70MPLvsYXqEXvR0TvH7qF-j79edv2111c_tlv726qZwQLFeu0VJK2tlWtV3DVK90Cw6ElMAa4qjWSraWt7ypBZU9LVUwCb0DqkCrml-gj6vuw9JO0Lnivng3D7Of7PxoovXm303wg7mPRyMk15rwIvD-SWCOPxdI2Uw-ORhHGyAuydC65g0vL1X_gRKmZAFpQasVdXNMaYb-5IgS8ztBsyZo1gQL_-7vM070n8gK8HYFDinH-bQXvCaa0Yb_Ahj6oyw</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Ivers, Louise</creator><creator>Charles, Richelle C.</creator><creator>Hilaire, Isabelle J.</creator><creator>Mayo-Smith, Leslie M.</creator><creator>Teng, Jessica E.</creator><creator>Jerome, J. 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Gregory ; Rychert, Jenna ; LaRocque, Regina C. ; Xu, Peng ; Kováč, Pavol ; Ryan, Edward T. ; Qadri, Firdausi ; Almazor, Charles P. ; Franke, Molly F. ; Harris, Jason B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-c895551dab6bd826f69bece455e280c19965ba3b387415f1741425efce16e9673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>BACTERIA</topic><topic>Blood Bactericidal Activity</topic><topic>CD4 Lymphocyte Count</topic><topic>Cholera - prevention & control</topic><topic>Cholera Vaccines - administration & dosage</topic><topic>Cholera Vaccines - immunology</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Haiti</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - immunology</topic><topic>Humans</topic><topic>Immunoglobulin A - blood</topic><topic>Lentivirus</topic><topic>Major and Brief Reports</topic><topic>Male</topic><topic>Microbial Viability</topic><topic>Middle Aged</topic><topic>Retroviridae</topic><topic>Vibrio cholerae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ivers, Louise</creatorcontrib><creatorcontrib>Charles, Richelle C.</creatorcontrib><creatorcontrib>Hilaire, Isabelle J.</creatorcontrib><creatorcontrib>Mayo-Smith, Leslie M.</creatorcontrib><creatorcontrib>Teng, Jessica E.</creatorcontrib><creatorcontrib>Jerome, J. 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| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2015-09, Vol.212 (5), p.779-783 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Oxford Journals Online |
| subjects | Administration, Oral Adult BACTERIA Blood Bactericidal Activity CD4 Lymphocyte Count Cholera - prevention & control Cholera Vaccines - administration & dosage Cholera Vaccines - immunology Cohort Studies Female Haiti HIV Infections - complications HIV Infections - immunology Humans Immunoglobulin A - blood Lentivirus Major and Brief Reports Male Microbial Viability Middle Aged Retroviridae Vibrio cholerae |
| title | Immunogenicity of the Bivalent Oral Cholera Vaccine Shanchol in Haitian Adults With HIV Infection |
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