Characterization of a Clone of Mycobacterium tuberculosis Clinical Isolates with Mutations in KatG (A110V), EthA (Q269STOP), and the inhA Promoter (-15C→T)

Among the Mycobacterium tuberculosis clinical isolates collected during the 2003-2014 period at the French National Reference Center for Mycobacteria, 29 showed a remarkable combination of mutations in katG, ethA, and the inhA promoter. The aim of this study was to establish the epidemiologic and mo...

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Bibliographic Details
Published in:Journal of clinical microbiology 2015-09, Vol.53 (9), p.3104-3104
Main Authors: Brossier, Florence, Sola, Christophe, Bernard, Christine, Jarlier, Vincent, Veziris, Nicolas, Sougakoff, Wladimir
Format: Article
Language:English
Subjects:
Bacterial Proteins - genetics
Catalase - genetics
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
Genotype
Humans
Letters to the Editor
Life Sciences
Microbiology and Parasitology
Molecular Sequence Data
Mutation
Mycobacterium tuberculosis - classification
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Oxidoreductases - genetics
Promoter Regions, Genetic
Sequence Analysis, DNA
Tuberculosis - microbiology
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Summary:Among the Mycobacterium tuberculosis clinical isolates collected during the 2003-2014 period at the French National Reference Center for Mycobacteria, 29 showed a remarkable combination of mutations in katG, ethA, and the inhA promoter. The aim of this study was to establish the epidemiologic and molecular features of these isolates.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.01537-15