Low CD1c + myeloid dendritic cell counts correlated with a high risk of rapid disease progression during early HIV-1 infection

During early HIV-1 infection (EHI), the interaction between the immune response and the virus determines disease progression. Although CD1c + myeloid dendritic cells (mDCs) can trigger the immune response, the relationship between CD1c + mDC alteration and disease progression has not yet been define...

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Bibliographic Details
Published in:BMC infectious diseases 2015-08, Vol.15 (1), p.342-342, Article 342
Main Authors: Diao, Yingying, Geng, Wenqing, Fan, Xuejie, Cui, Hualu, Sun, Hong, Jiang, Yongjun, Wang, Yanan, Sun, Amy, Shang, Hong
Format: Article
Language:English
Subjects:
Adult
Antigens, CD1 - immunology
CD4-Positive T-Lymphocytes - immunology
China
Cohort Studies
Comparative analysis
Dendritic Cells - immunology
Disease Progression
Flow Cytometry
Glycoproteins - immunology
Health aspects
HIV Infections - immunology
HIV Infections - mortality
HIV-1 - immunology
Homosexuality, Male
Humans
Immune response
Interleukin-12 - metabolism
Kaplan-Meier Estimate
Male
Medical research
Medicine, Experimental
Myeloid Cells - immunology
Young Adult
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Summary:During early HIV-1 infection (EHI), the interaction between the immune response and the virus determines disease progression. Although CD1c + myeloid dendritic cells (mDCs) can trigger the immune response, the relationship between CD1c + mDC alteration and disease progression has not yet been defined. EHI changes in CD1c + mDC counts, surface marker (CD40, CD86, CD83) expression, and IL-12 secretion were assessed by flow cytometry in 29 patients. When compared with the normal controls, patients with EHI displayed significantly lower CD1c + mDC counts and IL-12 secretion and increased surface markers. CD1c + mDC counts were positively correlated with CD4+ T cell counts and inversely associated with viral loads. IL-12 secretion was only positively associated with CD4+ T cell counts. Rapid progressors had lower counts, CD86 expression, and IL-12 secretion of CD1c + mDCs comparing with typical progressors. Kaplan-Meier analysis and Cox regression models suggested patients with low CD1c + mDC counts (
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-015-1092-8