Radial endobronchial ultrasound in diagnosing peripheral lung lesions in a high tuberculosis setting

Current data for the utility of radial endobronchial ultrasound (EBUS) in investigating peripheral lung lesions (PLLs) has been restricted to populations with low pulmonary tuberculosis (TB) incidence. The aim of this study was to assess the diagnostic utility of radial EBUS with guide sheath in the...

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Bibliographic Details
Published in:BMC pulmonary medicine 2015-08, Vol.15 (1), p.90-90, Article 90
Main Authors: Chan, Adrian, Devanand, Anantham, Low, Su Ying, Koh, Mariko Siyue
Format: Article
Language:English
Subjects:
Aged
Bronchoscopy
Bronchoscopy - methods
Care and treatment
Complications and side effects
Diagnosis, Differential
Endosonography - methods
Female
Follow-Up Studies
Humans
Lung diseases
Lung Neoplasms - complications
Lung Neoplasms - diagnosis
Male
Middle Aged
Patient outcomes
Predictive Value of Tests
Reproducibility of Results
Retrospective Studies
Risk factors
Tomography, X-Ray Computed
Tuberculosis
Tuberculosis, Pulmonary - complications
Tuberculosis, Pulmonary - diagnosis
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Summary:Current data for the utility of radial endobronchial ultrasound (EBUS) in investigating peripheral lung lesions (PLLs) has been restricted to populations with low pulmonary tuberculosis (TB) incidence. The aim of this study was to assess the diagnostic utility of radial EBUS with guide sheath in the diagnosis of peripheral lung lesions in Singapore, a high TB incidence setting. A post-hoc database analysis was performed. 123 consecutive patients with computed tomographic evidence of PLLs who underwent radial EBUS guided bronchoscopy were included. The final diagnosis was malignancy in 76 cases and benign in 44 cases. Radial EBUS guided bronchoscopy had a sensitivity of 65.8 % for malignancy, positive predictive value of 100 %, negative predictive value of 62.9 %, and a diagnostic accuracy of 82.5 %. 22 patients had a final diagnosis of pulmonary TB. The diagnostic sensitivity for pulmonary TB was 77.3 %, with a positive predictive value of 100 %, negative predictive value of 95.2 % and a diagnostic accuracy of 95.8 %. Overall, 58.8 % of pulmonary TB cases relied on histology to make an early diagnosis. Radial EBUS guided bronchosopy is useful in investigating PLLs in a high TB incidence setting. Our data also suggests that radial EBUS is a more rapid diagnosis technique for tuberculous lesions.
ISSN:1471-2466
1471-2466
DOI:10.1186/s12890-015-0089-9