Evolution of Influenza B Virus in Kuala Lumpur, Malaysia, between 1995 and 2008

Influenza B virus causes significant disease but remains understudied in tropical regions. We sequenced 72 influenza B viruses collected in Kuala Lumpur, Malaysia, from 1995 to 2008. The predominant circulating lineage (Victoria or Yamagata) changed every 1 to 3 years, and these shifts were associat...

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Bibliographic Details
Published in:Journal of virology 2015-09, Vol.89 (18), p.9689-9692
Main Authors: Sam, I-Ching, Su, Yvonne C F, Chan, Yoke Fun, Nor'E, Siti Sarah, Hassan, Ardalinah, Jafar, Faizatul Lela, Joseph, Udayan, Halpin, Rebecca A, Ghedin, Elodie, Hooi, Poh Sim, Fourment, Mathieu, Hassan, Hamimah, AbuBakar, Sazaly, Wentworth, David E, Smith, Gavin J D
Format: Article
Language:English
Subjects:
Base Sequence
Evolution, Molecular
Female
Genetic Diversity and Evolution
Humans
Influenza B virus - genetics
Influenza, Human - epidemiology
Influenza, Human - genetics
Malaysia - epidemiology
Male
Molecular Sequence Data
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Summary:Influenza B virus causes significant disease but remains understudied in tropical regions. We sequenced 72 influenza B viruses collected in Kuala Lumpur, Malaysia, from 1995 to 2008. The predominant circulating lineage (Victoria or Yamagata) changed every 1 to 3 years, and these shifts were associated with increased incidence of influenza B. We also found poor lineage matches with recommended influenza virus vaccine strains. While most influenza B virus lineages in Malaysia were short-lived, one circulated for 3 to 4 years.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.00708-15