Effect of ethnicity and socioeconomic variation to the gut microbiota composition among pre-adolescent in Malaysia

Gut microbiota plays an important role in mammalian host metabolism and physiological functions. The functions are particularly important in young children where rapid mental and physical developments are taking place. Nevertheless, little is known about the gut microbiome and the factors that contr...

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Bibliographic Details
Published in:Scientific reports 2015-08, Vol.5 (1), p.13338-13338, Article 13338
Main Authors: Chong, Chun Wie, Ahmad, Arine Fadzlun, Lim, Yvonne Ai Lian, Teh, Cindy Shuan Ju, Yap, Ivan Kok Seng, Lee, Soo Ching, Chin, Yuee Teng, Loke, P’ng, Chua, Kek Heng
Format: Article
Language:English
Subjects:
631/326/2565/2134
631/326/2565/2142
631/326/41/2530
Adolescent
Adolescents
Biodiversity
Chemotaxis
Child
Children
DNA, Ribosomal - genetics
Ethnic Groups
Ethnicity
Feces - microbiology
Female
Gastrointestinal Microbiome
High-Throughput Nucleotide Sequencing
Humanities and Social Sciences
Humans
Hygiene
Intestinal microflora
Linear Models
Malaysia
Male
Metabolism
Minority & ethnic groups
Multiculturalism & pluralism
multidisciplinary
Phylogeny
Polymorphism, Restriction Fragment Length
Principal Component Analysis
Science
Socioeconomic Factors
Socioeconomics
Sugar
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Summary:Gut microbiota plays an important role in mammalian host metabolism and physiological functions. The functions are particularly important in young children where rapid mental and physical developments are taking place. Nevertheless, little is known about the gut microbiome and the factors that contribute to microbial variation in the gut of South East Asian children. Here, we compared the gut bacterial richness and composition of pre-adolescence in Northern Malaysia. Our subjects covered three distinct ethnic groups with relatively narrow range of socioeconomic discrepancy. These included the Malays (n = 24), Chinese (n = 17) and the Orang Asli (indigenous) (n = 20). Our results suggested a strong ethnicity and socioeconomic-linked bacterial diversity. Highest bacterial diversity was detected from the economically deprived indigenous children while the lowest diversity was recorded from the relatively wealthy Chinese children. In addition, predicted functional metagenome profiling suggested an over-representation of pathways pertinent to bacterial colonisation and chemotaxis in the former while the latter exhibited enriched gene pathways related to sugar metabolism.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep13338