Comparative Assessment of Different Health Utility Measures in Systemic Lupus Erythematosus

In a time of increasing economic constraints, it is crucial that health systems optimize their resource use to ensure that they generate the maximum possible health gain. Therefore, it is necessary for health interventions to be evaluated and compared across therapeutic boundaries. Undertaking such...

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Bibliographic Details
Published in:Scientific reports 2015-08, Vol.5 (1), p.13297-13297, Article 13297
Main Authors: Wang, Su-li, Hsieh, Evelyn, Zhu, Li-an, Wu, Bin, Lu, Liang-jing
Format: Article
Language:English
Subjects:
692/700/1538
692/700/784
Adult
Autoimmune diseases
Demography
Female
Health promotion
Health Status
Humanities and Social Sciences
Humans
Immunology
Lupus
Lupus Erythematosus, Systemic - therapy
Male
multidisciplinary
Patient Acceptance of Health Care
Quality of Life
Regression Analysis
Reproducibility of Results
Science
Science (multidisciplinary)
Severity of Illness Index
Statistics, Nonparametric
Systemic lupus erythematosus
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Summary:In a time of increasing economic constraints, it is crucial that health systems optimize their resource use to ensure that they generate the maximum possible health gain. Therefore, it is necessary for health interventions to be evaluated and compared across therapeutic boundaries. Undertaking such an evaluation a generic utility-based measure is required. But it remains uncertain whether the utility values obtained by direct or indirect methods are comparable and which approach is the most appropriate in Systemic Lupus Erythematosus (SLE) population. In the study, we compared the utility values obtained by an indirect method (EQ-5D) with direct utility instruments, the standard gamble (SG) and visual analog scale (VAS), in SLE patients. The correlations between VAS, EQ-5D and LupusQoL were significant; relative good intraclass correlations or kappa coefficients indicated the reliability of these instruments. A model incorporating the SLEDAI scores and LupusQoL domains of emotional health and pain was a good predictor of VAS. SLEDAI score was a good predictor in the SG regression model. These findings suggested that the VAS and EQ-5D might be valid and reliable measures to assess health related quality of life in SLE patients and represent promising outcome measures for future research in this population.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep13297