Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes: Insights Into Molecular, Cellular, and Functional Phenotypes

Disease models are essential for understanding cardiovascular disease pathogenesis and developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology has generated significant enthusiasm for its potential application in basic and translational cardiac research. Patient-specif...

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Bibliographic Details
Published in:Circulation research 2015-06, Vol.117 (1), p.80-88
Main Authors: Karakikes, Ioannis, Ameen, Mohamed, Termglinchan, Vittavat, Wu, Joseph C
Format: Article
Language:English
Subjects:
Action Potentials
Bioengineering - methods
Calcium Signaling
Cardiovascular Diseases - pathology
Cations - metabolism
Cell Culture Techniques
Cell Differentiation
Cell Lineage
Drug Evaluation, Preclinical - methods
Electrophysiology
Energy Metabolism
Excitation Contraction Coupling
Fetal Heart - cytology
Gene Expression Profiling
Humans
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - drug effects
Induced Pluripotent Stem Cells - metabolism
Ion Channels - metabolism
Myocardial Contraction
Myocytes, Cardiac - classification
Myocytes, Cardiac - cytology
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - ultrastructure
Phenotype
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Summary:Disease models are essential for understanding cardiovascular disease pathogenesis and developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology has generated significant enthusiasm for its potential application in basic and translational cardiac research. Patient-specific iPSC-derived cardiomyocytes offer an attractive experimental platform to model cardiovascular diseases, study the earliest stages of human development, accelerate predictive drug toxicology tests, and advance potential regenerative therapies. Harnessing the power of iPSC-derived cardiomyocytes could eliminate confounding species-specific and interpersonal variations and ultimately pave the way for the development of personalized medicine for cardiovascular diseases. However, the predictive power of iPSC-derived cardiomyocytes as a valuable model is contingent on comprehensive and rigorous molecular and functional characterization.
ISSN:0009-7330
1524-4571
DOI:10.1161/CIRCRESAHA.117.305365